Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy
Autore:
Wielockx, B; Lannoy, K; Shapiro, SD; Itoh, T; Itohara, S; Vandekerckhove, J; Libert, C;
Indirizzi:
Flanders Interuniv Inst Biotechnol, Dept Mol Biol, Ghent, Belgium FlandersInteruniv Inst Biotechnol Ghent Belgium l Biol, Ghent, Belgium State Univ Ghent, B-9000 Ghent, Belgium State Univ Ghent Ghent Belgium B-9000 Univ Ghent, B-9000 Ghent, Belgium Washington Univ, Med Ctr, Jewish Hosp, Dept Med, St Louis, MO USA Washington Univ St Louis MO USA Jewish Hosp, Dept Med, St Louis, MO USA Shionogi & Co Ltd, Shionogi Inst Med Sci, Osaka, Japan Shionogi & Co Ltd Osaka Japan Ltd, Shionogi Inst Med Sci, Osaka, Japan RIKEN Brain Sci Inst, Lab Behav Genet, Wako, Saitama, Japan RIKEN Brain Sci Inst Wako Saitama Japan ehav Genet, Wako, Saitama, Japan Flanders Interuniv Inst Biotechnol, Dept Biochem, Ghent, Belgium Flanders Interuniv Inst Biotechnol Ghent Belgium iochem, Ghent, Belgium
Titolo Testata:
NATURE MEDICINE
fascicolo: 11, volume: 7, anno: 2001,
pagine: 1202 - 1208
SICI:
1078-8956(200111)7:11<1202:IOMMBL>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
TNF-ALPHA; ALPHA(1)-ACID GLYCOPROTEIN; PROINFLAMMATORY MEDIATORS; EXTRACELLULAR-MATRIX; LIVER-FAILURE; MICE; GELATINASE; ACTIVATION; ARTHRITIS; ANGIOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Libert, C Flanders Interuniv Inst Biotechnol, Dept Mol Biol, Ghent, Belgium Flanders Interuniv Inst Biotechnol Ghent Belgium ent, Belgium
Citazione:
B. Wielockx et al., "Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy", NAT MED, 7(11), 2001, pp. 1202-1208

Abstract

Acute and fulminant liver failure induced by viral hepatitis, alcohol or other hepatotoxic drugs, are associated with tumor necrosis factor (TNF) production. In a mouse model of lethal hepatitis induced by TNF, apoptosis andnecrosis of hepatocytes, but also lethality, hypothermia and influx of leukocytes into the liver, are prevented by a broad-spectrum matrix metalloproteinase (MMP) inhibitor, BB-94. Mice deficient in MMP-2, MMP-3 or MMP-9 hadlower levels of apoptosis and necrosis of hepatocytes, and better survival. We found induction of MMP-9 activity and fibronectin degradation. Our findings suggest that several MMPs play a critical role in acute, fulminant hepatitis by degrading the extracellular matrix and allowing massive leukocyte influx in the liver. BB-94 also prevented lethality in TNF/interferon-gamma therapy in tumor-bearing mice. A broad-spectrum MMP inhibitor may be potentially useful for the treatment of patients with acute and perhaps chronic liver failure, and in cancer therapies using inflammatory cytokines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:35:14