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Titolo:
Polymeric system for dual growth factor delivery
Autore:
Richardson, TP; Peters, MC; Ennett, AB; Mooney, DJ;
Indirizzi:
Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Biomed Engn, Ann Arbor, MI 48109 USA Univ Michigan, Dept Biol & Mat Sci, Ann Arbor, MI 48109 USA Univ MichiganAnn Arbor MI USA 48109 l & Mat Sci, Ann Arbor, MI 48109 USA Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 t Chem Engn, Ann Arbor, MI 48109 USA
Titolo Testata:
NATURE BIOTECHNOLOGY
fascicolo: 11, volume: 19, anno: 2001,
pagine: 1029 - 1034
SICI:
1087-0156(200111)19:11<1029:PSFDGF>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-VESSEL FORMATION; DRUG-DELIVERY; ANGIOGENESIS; RELEASE; MACROMOLECULES; EXPRESSION; MECHANISMS; SCAFFOLDS; PROTEINS; MATRICES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Mooney, DJ Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 , Ann Arbor, MI 48109 USA
Citazione:
T.P. Richardson et al., "Polymeric system for dual growth factor delivery", NAT BIOTECH, 19(11), 2001, pp. 1029-1034

Abstract

The development of tissues and organs is typically driven by the action ofa number of growth factors. However, efforts to regenerate tissues (e.g., bone, blood vessels) typically rely on the delivery of single factors, and this may partially explain the limited clinical utility of many current approaches. One constraint on delivering appropriate combinations of factors is a lack of delivery vehicles that allow for a localized and controlled delivery of more than a single factor. We report a new polymeric system that allows for the tissue-specific delivery of two or more growth factors, with controlled dose and rate of delivery. The utility of this system was investigated in the context of therapeutic angiogenesis. We now demonstrate that dual delivery of vascular endothelial growth factor (VEGF)-165 and platelet-derived growth factor (PDGF)-BB, each with distinct kinetics, from a single, structural polymer scaffold results in the rapid formation of a mature vascular network. This is the first report of a vehicle capable of delivery of multiple angiogenic factors with distinct kinetics, and these results clearly indicate the importance of multiple growth factor action in tissue regeneration and engineering.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:13:17