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Titolo:
Abnormal fetal growth is not associated with altered chorionic villous expression of vascular endothelial growth factor mRNA
Autore:
Lash, G; MacPherson, A; Liu, D; Smith, D; Charnock-Jones, S; Baker, P;
Indirizzi:
Univ Nottingham, City Hosp, Sch Human Dev, Nottingham NG7 2RD, England Univ Nottingham Nottingham England NG7 2RD , Nottingham NG7 2RD, England Univ Cambridge, Rosie Matern Hosp, Dept Obstet & Gynaecol, Cambridge, England Univ Cambridge Cambridge England Obstet & Gynaecol, Cambridge, England
Titolo Testata:
MOLECULAR HUMAN REPRODUCTION
fascicolo: 11, volume: 7, anno: 2001,
pagine: 1093 - 1098
SICI:
1360-9947(200111)7:11<1093:AFGINA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN PLACENTAL VILLI; TYROSINE KINASE; MESSENGER-RNA; STEM VILLI; PREECLAMPSIA; PREGNANCIES; RECEPTOR; VEGF; TROPHOBLAST; PLASMA;
Keywords:
chorionic villous sampling; flt-1; intrauterine growth retardation; pregnancy; VEGF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Lash, G Queens Univ, Dept Anat & Cell Biol, 9th Floor Botterell Hall, Kingston, ONK7L 3N6, Canada Queens Univ 9th Floor Botterell Hall Kingston ON Canada K7L 3N6 da
Citazione:
G. Lash et al., "Abnormal fetal growth is not associated with altered chorionic villous expression of vascular endothelial growth factor mRNA", MOL HUM REP, 7(11), 2001, pp. 1093-1098

Abstract

Altered placental and circulating levels of vascular endothelial growth factor (VEGF) and its receptor (flt-1) may be associated with pre-eclampsia and intrauterine growth restriction (IUGR). The aim of this study was to determine whether chorionic villous VEGF or flt-1 mRNA are altered at early gestation in pregnancies subsequently found to be complicated by abnormal fetal growth. Quantitative reverse transcription-polymerase chain reaction wasperformed on chorionic villous samples for VEGF and flt-1 using an internal RNA standard. Using the individualized birthweight ratio (IBR), the subjects (n = 51) were divided into three groups; IUGR (IBR <10th centile, n = 6), normal (IBR 10th-90th centiles, n = 41) and macrosomic (IBR >90th centile, n = 4). There was no correlation between the mRNA expression of VEGF(121) or VEGF(165) and gestational age of the normal controls. There was also no difference in the expression of either of the VEGF isoforms between the IUGR or macrosomic groups and the normal controls. Expression of flt-1 was below the detection limit of the assay. In conclusion, we have found that altered chorionic villous expression of VEGF is not associated with the initial stages of development of IUGR or macrosomia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:48:12