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Titolo:
Comparative analysis of cyclin D1 and oestrogen receptor (alpha and beta) levels in human leiomyoma and adjacent myometrium
Autore:
Kovacs, KA; Oszter, A; Gocze, PM; Kornyei, JL; Szabo, I;
Indirizzi:
Univ Pecs, Sch Med, Dept Obstet & Gynecol, H-7624 Pecs, Hungary Univ PecsPecs Hungary H-7624 ept Obstet & Gynecol, H-7624 Pecs, Hungary Univ Pecs, Sch Med, Inst Physiol, H-7643 Pecs, Hungary Univ Pecs Pecs Hungary H-7643 ch Med, Inst Physiol, H-7643 Pecs, Hungary
Titolo Testata:
MOLECULAR HUMAN REPRODUCTION
fascicolo: 11, volume: 7, anno: 2001,
pagine: 1085 - 1091
SICI:
1360-9947(200111)7:11<1085:CAOCDA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RIBONUCLEIC-ACID; ESTRADIOL BINDING-SITES; SEX STEROID-RECEPTORS; ESTROGEN-RECEPTOR; RAT UTERUS; OPIOID-PEPTIDES; PROGESTERONE-RECEPTOR; ANATOMICAL VARIATION; GENE-EXPRESSION; MENSTRUAL-CYCLE;
Keywords:
cyclin D1; human leiomyoma; oestrogen receptors; menopause; menstrual cycle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Kovacs, KA Univ Pecs, Sch Med, Dept Obstet & Gynecol, Edesanyak 13-15, H-7624 Pecs, Hungary Univ Pecs Edesanyak 13-15 Pecs Hungary H-7624 24 Pecs, Hungary
Citazione:
K.A. Kovacs et al., "Comparative analysis of cyclin D1 and oestrogen receptor (alpha and beta) levels in human leiomyoma and adjacent myometrium", MOL HUM REP, 7(11), 2001, pp. 1085-1091

Abstract

The aim of these experiments was to investigate the expression of cyclin D1 and of oestradiol receptors as well as the level of [H-3]oestradiol binding in leiomyoma and adjacent myometrium from human uteri at different menstrual phases and at an early stage of menopause. [H-3]oestradiol binding wasdetermined by saturation analysis, while the oestradiol receptor (ER) alpha and beta and cyclin D1 levels were determined by Western blot analysis of16 samples of human leiomyomas and corresponding myometria at different hormonal stages. In leiomyomas during all phases of the menstrual cycle, ER alpha expression, high affinity oestradiol binding and cyclin D1 expression were all elevated in comparison with adjacent myometrium. ER beta expression and low affinity oestradiol binding were enhanced in leiomyomas only during the proliferative phase. During menopause, ER beta expression and low affinity binding were enhanced in leiomyomas, while the ER alpha expression was not significantly enhanced and cyclin D1 levels were similar to that in myometrium. Only the oestradiol binding exhibited any menstrual cycle-related changes. Our data suggest the involvement of cyclin D1 in the growth of leiomyomas during the menstrual cycle. In menopause, there appears to be a switch from ER alpha to ER beta expression in leiomyomas, and the inductionof cyclin D1 is decreased. The regression of tumour may ensue from these changes at menopause.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 15:06:15