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Titolo:
Linkage and association studies of the relationship between endometriosis and genes encoding the detoxification enzymes GSTM1, GSTT1 and CYP1A1
Autore:
Hadfield, RM; Manek, S; Weeks, DE; Mardon, HJ; Barlow, DH; Kennedy, SH;
Indirizzi:
Univ Oxford, John Radcliffe Hosp, Nuffield Dept Obstet & Gynaecol, Oxford OX3 9DU, England Univ Oxford Oxford England OX3 9DU t & Gynaecol, Oxford OX3 9DU, England John Radcliffe Hosp, Dept Cellular Pathol, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU thol, Oxford OX3 9DU, England Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 n Genet, Pittsburgh, PA 15260 USA
Titolo Testata:
MOLECULAR HUMAN REPRODUCTION
fascicolo: 11, volume: 7, anno: 2001,
pagine: 1073 - 1078
SICI:
1360-9947(200111)7:11<1073:LAASOT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUNG-CANCER SUSCEPTIBILITY; S-TRANSFERASE GSTM1; POLYMORPHISM; M1; GENOTYPES; 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN; GSTM1-0/0-GENOTYPE; INDUCIBILITY; EXPRESSION; COMPLEX;
Keywords:
CYP1A1; endometriosis; genetics; GSTM1; GSTT1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Kennedy, SH Univ Oxford, John Radcliffe Hosp, Nuffield Dept Obstet & Gynaecol, Oxford OX3 9DU, England Univ Oxford Oxford England OX3 9DU , Oxford OX3 9DU, England
Citazione:
R.M. Hadfield et al., "Linkage and association studies of the relationship between endometriosis and genes encoding the detoxification enzymes GSTM1, GSTT1 and CYP1A1", MOL HUM REP, 7(11), 2001, pp. 1073-1078

Abstract

An association between endometriosis and the glutathione S-transferase (GST) M1 null mutation has been reported in French and Slavic populations. We aimed to replicate this association of endometriosis in a UK population, and to test for association with the GSTT1 null mutation or the cytochrome P450 (CYP) 1A1 MspI polymorphism. We genotyped 148 women each with endometriosis (sporadic cases, n = 91; familial cases, n = 57), a population control of 95 male blood donors, and a control group of 53 women with a normal pelvis at hysterectomy. No significant differences were found between cases andcontrols in the frequencies of the GSTM1 and GSTT1 null mutations, or the CYP1A1 MspI polymorphism. However, the combination of the GSTM1 null genotype and the CYP1A1 MspI polymorphism was associated with a small increased risk of endometriosis, and this warrants further investigation. We also tested for linkage to the chromosome 1p13 region, to which GSTM1 has been mapped, in 52 sister-pairs with stage III-IV disease using three highly polymorphic microsatellite markers. However, there was no evidence of linkage, suggesting that this region may not be implicated in disease susceptibility.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 12:45:02