Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Prostate-specific antigen, testosterone, sex-hormone binding globulin and androgen receptor CAG repeat polymorphisms in subfertile and normal men
Autore:
Mifsud, A; Choon, AT; Fang, D; Yong, EL;
Indirizzi:
Natl Univ Singapore Hosp, Dept Obstet & Gynaecol, Singapore 119074, Singapore Natl Univ Singapore Hosp Singapore Singapore 119074 re 119074, Singapore Natl Univ Singapore Hosp, Dept Lab Med, Singapore 119074, Singapore Natl Univ Singapore Hosp Singapore Singapore 119074 re 119074, Singapore Natl Univ Singapore Hosp, Dept Biostat, Singapore 119074, Singapore Natl Univ Singapore Hosp Singapore Singapore 119074 re 119074, Singapore
Titolo Testata:
MOLECULAR HUMAN REPRODUCTION
fascicolo: 11, volume: 7, anno: 2001,
pagine: 1007 - 1013
SICI:
1360-9947(200111)7:11<1007:PATSBG>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER RISK; TRINUCLEOTIDE REPEATS; POLYGLUTAMINE TRACTS; SERUM TESTOSTERONE; GENE; ESTROGEN; TRANSACTIVATION; INFERTILITY; MARKERS; LENGTH;
Keywords:
androgen receptor; infertility; prostate-specific antigen; testosterone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Mifsud, A Natl Univ Singapore Hosp, Dept Obstet & Gynaecol, Level 2,Lower Kent RidgeRd, Singapore 119074, Singapore Natl Univ Singapore Hosp Level 2,Lower Kent Ridge Rd Singapore Singapore 119074
Citazione:
A. Mifsud et al., "Prostate-specific antigen, testosterone, sex-hormone binding globulin and androgen receptor CAG repeat polymorphisms in subfertile and normal men", MOL HUM REP, 7(11), 2001, pp. 1007-1013

Abstract

The aim of this study was to understand the androgen-related factors whichmay regulate concentrations of the tumour marker, prostate-specific antigen (PSA). We therefore measured the serum concentrations of total and free testosterone and of sex hormone-binding globulin (SHBG) and determined the androgen receptor (AR) gene CAG repeat length, then compared these values tototal and free PSA concentrations in 91 subjects with proven fertility, and 112 subfertile men with defective spermatogenesis. Concentrations of freetestosterone and total testosterone, adjusted for SHBG, were 17-20% lower in subfertile men compared with those in their fertile counterparts. This subtle, but highly significant (P < 0.001), difference in testosterone between fertile and subfertile men was accentuated by the positive correlation between testosterone and AR gene CAG repeat length in fertile, but not subfertile, subjects. In subfertile subjects, testosterone strongly correlated (r = 0.354, P < 0.001) with PSA concentrations, and independent of testosterone, total PSA negatively correlated (r = -0.229, P = 0.011) with AR CAG length. Overall our data suggest that, firstly, PSA correlates with testosterone only in an environment of relatively low androgenicity, such as in subfertile men. Secondly, in such a low androgenic environment, short CAG tracts (associated with high AR activity) correlate positively with PSA concentrations. These results suggest that interpretation of PSA is best made in conjunction with testosterone concentrations and AR CAG length.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:44:42