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Titolo:
Chromosomal abnormalities in oocytes
Autore:
Plachot, M;
Indirizzi:
CHI Jean Rostand, Lab Fecondat In Vitro, F-92310 Sevres, France CHI Jean Rostand Sevres France F-92310 In Vitro, F-92310 Sevres, France
Titolo Testata:
MOLECULAR AND CELLULAR ENDOCRINOLOGY
, volume: 183, anno: 2001, supplemento:, 1
pagine: S59 - S63
SICI:
0303-7207(20011022)183:<S59:CAIO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACYTOPLASMIC SPERM INJECTION; UNFERTILIZED HUMAN OOCYTES; IN-VITRO FERTILIZATION; CYTOGENETIC ANALYSIS; INVITRO FERTILIZATION; ANEUPLOIDY; MATURATION; DIAGNOSIS; FEMALE; ORIGIN;
Keywords:
human oocytes; in vitro fertilization; chromosome abnormalities;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Plachot, M CHI Jean Rostand, Lab Fecondat In Vitro, 141 Grande Rue, F-92310 Sevres, France CHI Jean Rostand 141 Grande Rue Sevres France F-92310 , France
Citazione:
M. Plachot, "Chromosomal abnormalities in oocytes", MOL C ENDOC, 183, 2001, pp. S59-S63

Abstract

Since the beginning of in vitro fertilization (IVF), basic research has provided insight in the field of human reproduction, especially in genetics. Indeed. the contribution of chromosomal abnormalities to oocyte disorders and impaired embryonic development is now well known. Of oocytes that fail to fertilize after in vitro insemination, 26.5% have been found to be abnormal. with 13.3% showing hypohaploidy, hyperhaploidy, 1.6% structural abnormalities and 3.5% diploidy. The total incidence of abnormalities seems to be correlated with the fertility status of the woman, It is higher in oocytes from women with tubal or unexplained infertility than in those from women whose husband's infertility is the sole cause of infertility in the couple. Although few oocytes recovered during natural cycles have been studied, gonadotropins, which are widely used to stimulate follicle growth and ovulation, do not increase the risk of abnormalities. The effect of maternal age onfetal aneuploidy, well documented at birth, has not been unambiguously shown to result from an increase in the frequency of aneuploid oocytes. Intra-and extra-follicular influences (perifollicular micro asculature, oxygenation, and the presence of residues from cigarette smoke) may disturb maturation. leading to immaturity and aneuploidy. Thus, oocyte meiosis is very sensitive to endogenous and exogenous factors that could result in oocytes with chromosomal abnormalities and therefore. abnormal zygotes. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 15:45:24