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Titolo:
Combined high-speed NMR imaging of perfusion and microscopic coronary conductance vessels in the isolated rat heart
Autore:
Hiller, KH; Waller, C; Voll, S; Haase, A; Ertl, G; Bauer, WR;
Indirizzi:
Univ Wurzburg, Inst Phys, D-97074 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97074 t Phys, D-97074 Wurzburg, Germany Univ Wurzburg, Med Klin, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 d Klin, D-97080 Wurzburg, Germany
Titolo Testata:
MICROVASCULAR RESEARCH
fascicolo: 3, volume: 62, anno: 2001,
pagine: 327 - 334
SICI:
0026-2862(200111)62:3<327:CHNIOP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SNAPSHOT-FLASH MRI; COLORED MICROSPHERES; MICROCIRCULATION; T1; NITROGLYCERIN; ENDOTHELIN-1; MYOCARDIUM; EXCHANGE;
Keywords:
experimental; NMR; microcirculation; regional blood flow; vasodilation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Hiller, KH Univ Wurzburg, Inst Phys, D-97074 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97074 7074 Wurzburg, Germany
Citazione:
K.H. Hiller et al., "Combined high-speed NMR imaging of perfusion and microscopic coronary conductance vessels in the isolated rat heart", MICROVASC R, 62(3), 2001, pp. 327-334

Abstract

Noninvasive characterization of microcirculation at the level of both coronary conductance and resistance vessels is of major importance for the understanding of microvascular adaptive processes in the heart. The objective of this study was to determine simultaneously myocardial perfusion and microvessel diameters in the myocardium by magnetic resonance (MR) imaging within the same heart. A MR imaging method is presented which combines high-resolution perfusion measurement (140 X 140 mum(2)) by spin labeling with flow-weighted MR microscopy of coronary microvessels (phi > 140 mum). We determined changes in myocardial perfusion and vessel diameters of isolated beating rat hearts (n = 10) at rest and during administration of nitroglycerin (0.5 mg/min). Alterations in perfusion were validated by microsphere measurements. Under the influence of nitroglycerin an increase in perfusion (+2.51 /- 0.4 ml . min(-1) . g(-1), mean +/- SEM) and vessel diameters (+14.22 +/- 1.92%) could be observed. Endocardial perfusion revealed a modest enhanced susceptibility to nitroglycerin in comparison to epicardial perfusion. Analysis of vessels according to their diameters showed no significant differences. MR imaging allows the noninvasive and simultaneous determination of conducting arteries and smaller resistance vessels in one and the same beating rat heart. Due to an excellent spatial resolution of these methods, transmural characterization of both parameters at rest and during vasodilationis feasible. (C) 2001 Academic Press.

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Documento generato il 14/07/20 alle ore 18:56:03