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Titolo:
NO message from muscle
Autore:
Grozdanovic, Z;
Indirizzi:
Free Univ Berlin, Univ Klinikum Benjamin Franklin, Inst Anat, D-14195 Berlin, Germany Free Univ Berlin Berlin Germany D-14195 st Anat, D-14195 Berlin, Germany
Titolo Testata:
MICROSCOPY RESEARCH AND TECHNIQUE
fascicolo: 3, volume: 55, anno: 2001,
pagine: 148 - 153
SICI:
1059-910X(20011101)55:3<148:NMFM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE-SYNTHASE; DUCHENNE MUSCULAR-DYSTROPHY; SARCOPLASMIC-RETICULUM CA2+-ATPASE; DEFICIENT SKELETAL-MUSCLE; STRIATED-MUSCLE; RELAXING FACTOR; END-PLATE; RAT; COMPLEX; FIBERS;
Keywords:
nitric oxide; nitric oxide synthase; skeletal muscle; dystrophin; muscular dystrophy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Grozdanovic, Z Free Univ Berlin, Univ Klinikum Benjamin Franklin, Inst Anat, Koenigin Luise Str 15, D-14195 Berlin, Germany Free Univ Berlin KoeniginLuise Str 15 Berlin Germany D-14195
Citazione:
Z. Grozdanovic, "NO message from muscle", MICROSC RES, 55(3), 2001, pp. 148-153

Abstract

The synthesis of the free radical gas nitric oxide (NO) is catalyzed by the enzyme NO synthase (NOS). NOS converts arginine and molecular oxygen to NO and citrulline in a reaction that requires NADPH, FAD, FMN, and tetrahydrobiopterin as cofactors. Three types of NOS have been identified by molecular cloning. The activity of the constitutively expressed neuronal NOS (nNOS) and endothelial NOS (eNOS) is Ca2+/calmodulin-dependent,whereas that the inducible NOS (iNOS) is Ca2+-insensitive. The predominant NOS isoform in skeletal muscle is nNOS. It is present at the sarcolemma of both extra- and intrafusal muscle fibers. An accentuated accumulation of nNOS is found in the endplate area. This strict sarcolemmal localization of nNOS is due its association with the dystrophin-glycoprotein complex, which is mediated by the syntrophins. The activity of nNOS in skeletal muscle is regulated by developmental, myogenic, and neurogenic influences. NO exerts several distinct effects on various aspects of skeletal muscle function, such as excitation-contraction coupling, mitochondrial energy production, glucose metabolism, and autoregulation of blood flow. Inside the striated muscle fibers, NO interacts directly with several classes of proteins, such as soluble guanylatecyclase, ryanodine receptor, sarcoplasmic reticulum Ca2+- ATPase, glyceraldehyde-3-phosphate dehydrogenase, and mitochondrial respiratory chain complexes, as well as radical oxygen species. In addition, NO produced and released by contracting muscle flbers diffuses to nearby arterioles where it acts to inhibit reflex sympathetic vasoconstriction. Microsc. Res. Tech. 55:148-153, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:08:51