Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Allogeneic bone marrow transplantation in first remission rescues childrenwith Philadelphia chromosome-positive acute lymphoblastic leukemia: Tokyo Children's Cancer Study Group (TCCSG) studies L89-12 and L92-13
Autore:
Mori, T; Manabe, A; Tsuchida, M; Hanada, R; Yabe, H; Ohara, A; Saito, T; Nakazawa, S;
Indirizzi:
Univ Tokyo, Inst Med Sci, Dept Pediat Hematol Oncol, Minato Ku, Tokyo 1088639, Japan Univ Tokyo Tokyo Japan 1088639 ol Oncol, Minato Ku, Tokyo 1088639, Japan Social Insurance Saitamachuo Hosp, Dept Pediat, Tokyo, Japan Social Insurance Saitamachuo Hosp Tokyo Japan Dept Pediat, Tokyo, Japan Ibaraki Childrens Hosp, Dept Pediat, Tokyo, Japan Ibaraki Childrens Hosp Tokyo Japan rens Hosp, Dept Pediat, Tokyo, Japan Saitama Childrens Hosp, Dept Hematol Oncol, Tokyo, Japan Saitama ChildrensHosp Tokyo Japan sp, Dept Hematol Oncol, Tokyo, Japan Tokai Univ, Dept Pediat, Hiratsuka, Kanagawa 25912, Japan Tokai Univ Hiratsuka Kanagawa Japan 25912 iratsuka, Kanagawa 25912, Japan Yamanashi Med Univ, Dept Pediat, Yamanashi, Japan Yamanashi Med Univ Yamanashi Japan Univ, Dept Pediat, Yamanashi, Japan
Titolo Testata:
MEDICAL AND PEDIATRIC ONCOLOGY
fascicolo: 5, volume: 37, anno: 2001,
pagine: 426 - 431
SICI:
0098-1532(200111)37:5<426:ABMTIF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MINIMAL RESIDUAL DISEASE; PROGNOSTIC-SIGNIFICANCE; HIGH-RISK; CHILDHOOD; CHEMOTHERAPY;
Keywords:
acute lymphoblastic leukemia; Philadelphia chromosome; childhood cancer; bone marrow transplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Manabe, A Univ Tokyo, Inst Med Sci, Dept Pediat Hematol Oncol, Minato Ku, 4-6-1 Shirokanedai, Tokyo 1088639, Japan Univ Tokyo 4-6-1 Shirokanedai Tokyo Japan 1088639 088639, Japan
Citazione:
T. Mori et al., "Allogeneic bone marrow transplantation in first remission rescues childrenwith Philadelphia chromosome-positive acute lymphoblastic leukemia: Tokyo Children's Cancer Study Group (TCCSG) studies L89-12 and L92-13", MED PED ONC, 37(5), 2001, pp. 426-431

Abstract

Background. The prognosis of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is generally poor and reports from large studiesare scarce. We evaluated the efficacy of allogeneic bone marrow transplantation (allo-BMT) for children with this type of leukemia. Procedure. The chemotherapy regimens consisted of an induction phase and very intensive consolidation followed by a reinduction phase and late intensification treatment. The selection of treatment modalities such as chemotherapy, allo-BMT, orautologous transplantation was made by each institute. The principal endpoint was the outcome of children with Ph+ ALL according to the treatment options. Results. Thirty-two patients (4.3%) were diagnosed as Ph+ ALL out of the 741 cases of ALL consecutively enrolled in two protocols of the Tokyo Children's Cancer Study Group (TCCSG) from 1989 to 1994. Thirty patients (93.8%) were Induced into complete remission (CR). Of these 30 patients, eightchildren electively received allo-BMT in the first CR. Six of these patients are in continuous remission at a median follow-up of 58 (range 48-105) months after the diagnosis. One patient died following recurrence and another patient died of graft vs. host disease. Three patients treated with autologous BMT or peripheral blood stem cell transplantation in the first CR experienced a subsequent relapse, In the remaining 19 patients, 13 patients were treated with very high-risk chemotherapy alone and all relapsed within 28 months. One patient was excluded from the analysis because lie was treated with standard-risk chemotherapy until relapse. The other five patients were also excluded from the analysis because Philadelphia chromosome was not detected until they relapsed. None of the relapsed patients survived in spite of treatment including allo-BMT. In multivariate analysis, only allo-BMTremained as an independent factor for good prognosis. Conclusions. The only way to cure children with Ph+ ALL was allo-BMT in this study and its outcome seemed promising. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 08:07:00