Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Increased sputum IL-8 and IL-5 in asymptomatic nonspecific airway hyperresponsiveness
Autore:
Betz, R; Kohlhaufl, M; Kassner, G; Mullinger, B; Maier, K; Brand, P; Weber, N; Haussinger, K; Heyder, J; Frankenberger, M;
Indirizzi:
Asklepios Fachkliniken Munchen Gauting, Munich, Germany Asklepios Fachkliniken Munchen Gauting Munich Germany , Munich, Germany GSF, Inst Inhalat Biol, Clin Res Grp Aerosols Med, Munich, Germany GSF Munich Germany lat Biol, Clin Res Grp Aerosols Med, Munich, Germany
Titolo Testata:
LUNG
fascicolo: 2, volume: 179, anno: 2001,
pagine: 119 - 133
SICI:
0341-2040(200103/04)179:2<119:ISIAII>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSTRUCTIVE PULMONARY-DISEASE; BRONCHIAL HYPERRESPONSIVENESS; INFLAMMATORY MARKERS; ASTHMA; INTERLEUKIN-8; CELLS; COPD; EXACERBATIONS; MEDIATORS; SYMPTOMS;
Keywords:
asymptomatic nonspecific airway; hyperresponsiveness; airway inflammation; IL-8,IL-5; induced sputum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Frankenberger, M GSF, Inst Inhalat Biol, Clin Res Grp Aerosols Med, RobertKoch Allee 29, D-82131 Gauting, Germany GSF Robert Koch Allee 29 Gauting Germany D-82131 Germany
Citazione:
R. Betz et al., "Increased sputum IL-8 and IL-5 in asymptomatic nonspecific airway hyperresponsiveness", LUNG, 179(2), 2001, pp. 119-133

Abstract

Since asymptomatic, nonspecific airway hyperresponsiveness (BHR) may be due to an enhanced local inflammatory response, we studied molecular markers of inflammation in induced sputum from subjects with asymptomatic BHR (n = 14) compared with control subjects (n = 13) and patients with chronic obstructive pulmonary disease (COPD) (n = 10). Pulmonary lung function parameters were measured by spirometry and body plethysmography. Hyperresponsivenesswas defined based on histamine challenge. Induced sputum samples were collected and the solid phase was isolated and analyzed for leukocyte numbers and differential and for cytokines (ELISA). IL-8 was 2.4-fold increased (p =0.036) in the sputum of subjects with asymptomatic BHR (24.8 +/- 22.0 ng/mL; +/- SD) and 11.2-fold enhanced in patients with COPD (117.8 +/- 106.3 ng/mL) as compared with control subjects (10.5 +/- 7.7 ng/mL). In control subjects, no IL-5 was measured, however, sputum of those with asymptomatic BHRcontained IL-5 at 0.044 +/- 0.090 ng/mL fluid and COPD patients at 1.00 +/- 2.01 ng/mL. GM-CSF could not be detected in sputum samples of any subjects investigated. Number of total leukocytes was higher in those with asymptomatic BHR and COPD (with BHR: 9.4 +/- 10.8 x 10(5); COPD: 83.5 +/- 182.5 x 10(5)) compared with persons without BHR (2.9 +/- 3.4 x 10(5)). PMN were increased in patients with asymptomatic BHR (4.1 +/- 5.3 x 10(5)) (38.8 +/- 24.7%) and COPD (32.9 +/- 71.0 x 10(5)) (75.4 +/- 18.6%) compared with controls (0.7 +/- 0.9 x 10(5)) (25.8 +/- 25.7%). In contrast to PMN counts in those with asymptomatic BHR (0.06 +/- 0.11 x 10(5)) (1.5 +/- 3.7%), eosinophil counts were only slightly increased compared with control subjects (0.01 /- 0.02 x 10(5)) (0.6 +/- 0.9%). This study supports the hypothesis that BHR in asymptomatic people is associated with airway inflammation that may predispose to development of chronic diseases such as COPD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:58:11