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Titolo:
A mechanism of Ca2+ release from Ca2+ stores coupling to the Na+/Ca2+ exchanger in cultured smooth muscle cells
Autore:
Hisamitsu, T; Ohata, H; Kawanishi, T; Iwamoto, T; Shigekawa, M; Amano, H; Yamada, S; Momose, K;
Indirizzi:
Showa Univ, Sch Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku, Tokyo 1428555, Japan Showa Univ Tokyo Japan 1428555 macol, Shinagawa Ku, Tokyo 1428555, Japan Natl Inst Hlth Sci, Div Biol Chem & Biol, Setagaya Ku, Tokyo 1588501, Japan Natl Inst Hlth Sci Tokyo Japan 1588501 Setagaya Ku, Tokyo 1588501, Japan Natl Cardiovasc Ctr, Res Inst, Dept Mol Physiol, Suita, Osaka 5658565, Japan Natl Cardiovasc Ctr Suita Osaka Japan 5658565 Suita, Osaka 5658565, Japan Showa Univ, Sch Dent, Dept Pharmacol, Shinagawa Ku, Tokyo 1428555, Japan Showa Univ Tokyo Japan 1428555 macol, Shinagawa Ku, Tokyo 1428555, Japan
Titolo Testata:
LIFE SCIENCES
fascicolo: 23, volume: 69, anno: 2001,
pagine: 2775 - 2787
SICI:
0024-3205(20011026)69:23<2775:AMOCRF>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG ILEUM; SODIUM-CALCIUM EXCHANGE; SARCOPLASMIC-RETICULUM; NA+-CA2+ EXCHANGER; VENTRICULAR MYOCYTES; CONTRACTION; IDENTIFICATION; MOBILIZATION; ASTROCYTES; PROTEIN;
Keywords:
antisense; sodium/calcium exchange; ileum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Hisamitsu, T Showa Univ, Sch Pharmaceut Sci, Dept Pharmacol, Shinagawa Ku,Hatanodai 1-5-8, Tokyo 1428555, Japan Showa Univ Hatanodai 1-5-8 Tokyo Japan 1428555 428555, Japan
Citazione:
T. Hisamitsu et al., "A mechanism of Ca2+ release from Ca2+ stores coupling to the Na+/Ca2+ exchanger in cultured smooth muscle cells", LIFE SCI, 69(23), 2001, pp. 2775-2787

Abstract

We previously observed Ca2+ release from intracellular Call stores caused by reduction in extracellular Na+ concentration ([Na+](o)) (1). The purposeof this study was to determine whether lowering [Na+](o) can elicit Ca2+ release from Ca2+ stores via the Na+/Ca2+ exchanger and to elucidate the mechanisms related to the Ca2+ release pathway in cultured longitudinal smoothmuscle cells obtained from zn guinea pig ileum. Low [Na+](o)-induced Ca2+ release was inhibited by antisense oligodeoxynucleotides for Na+/Ca2+ exchanger type I (anti-NCX). Application of anti-NCX to cells attenuated both the number of Ca2+ responding cells and the expression of the exchanger. Moreover, microinjection of heparin, a blocker of inositol. 1,4,5-trisphosphate(IP3) receptors, into the cells inhibited low [Na+](o)-induced Ca2+ release. These findings suggest that low [Na+](o)-induced Call release occurs through an IP3-induced Ca2+ release mechanism due to changes in the Ca2+ flux regulated by the Na+/Ca2+ exchanger. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 22:41:37