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Titolo:
Influence of genetic variation in the major histocompatibility complex on head and neck cancer susceptibility.
Autore:
Matthias, C; Jahnke, V; Hajeer, A; Ollier, W; Fryer, AA; Strange, RC;
Indirizzi:
Humboldt Univ, Charite, HNO Klin & Poliklin, Berlin, Germany Humboldt Univ Berlin Germany rite, HNO Klin & Poliklin, Berlin, Germany Univ Manchester, ARC, Epidemiol Res Unit, Manchester, Lancs, England Univ Manchester Manchester Lancs England nit, Manchester, Lancs, England Keele Univ, Postgrad Med Sch, Clin Biochem Res Grp, Keele, Staffs, EnglandKeele Univ Keele Staffs England Biochem Res Grp, Keele, Staffs, England
Titolo Testata:
LARYNGO-RHINO-OTOLOGIE
fascicolo: 10, volume: 80, anno: 2001,
pagine: 595 - 600
SICI:
1615-0007(200110)80:10<595:IOGVIT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
GER
Soggetto:
TUMOR-NECROSIS-FACTOR; SQUAMOUS-CELL CARCINOMA; AERODIGESTIVE TRACT CANCERS; DEPENDENT DIABETES-MELLITUS; FACTOR-ALPHA; MICROSATELLITE POLYMORPHISMS; FACTOR TNF; ALLELES; ASSOCIATION; INSTABILITY;
Keywords:
MHC; TNF; pharyngeal cancer; laryngeal cancer; susceptibility; microsatellites;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Matthias, C Humboldt Univ, HNO Klin Charite, Campus Virchow Klinikum, Augustenburger Pl 1, D-13353 Berlin, Germany Humboldt Univ Augustenburger Pl 1 Berlin Germany D-13353 many
Citazione:
C. Matthias et al., "Influence of genetic variation in the major histocompatibility complex on head and neck cancer susceptibility.", LARY RH OTO, 80(10), 2001, pp. 595-600

Abstract

Background:While cigarette smoking and alcohol consumption are risk factors for squamous cell carcinomas (SCC) of the head and neck, genetic factors are also significant. The gene of tumor necrosis factor (TNF) is located inthe major histocompatibility complex class III and the cytokine has pleiotropic actions some of which are anticarcinogenic. As this gene complex is polymorphic with microsatellite markers identified it is a further candidatefor head and neck cancer susceptibility. Methods: We used a case-control approach to study the influence of polymorphism at the A-D markers on susceptibility in 113 controls, 265 laryngeal and 123 oral cavity/pharyngeal SCC cases. Genotypes were identified on polyacrylamide gels in an automated DNAsequencer after amplification with fluorescently-labeled primers. Results:We found no differences in allele frequencies between controls and oral cavity/pharyngeal SCC cases but the frequency of B3 was greater in the laryngeal SCC cases than controls (p = 0.004, odds ratio 2.8). Homozygosity for B3 conferred an increased risk of laryngeal cancer compared with controls (p= 0.021, odds ratio 10.8). Conclusions: The data provide the first evidence that allelism at MHC class III microsatellite markers is associated with risk to laryngeal SCC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/12/19 alle ore 01:29:45