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Titolo:
Age and gender effects on cardiomyocyte apoptosis in the normal human heart
Autore:
Mallat, Z; Fornes, P; Costagliola, R; Esposito, B; Belmin, JL; Lecomte, D; Tedgui, A;
Indirizzi:
Hop Rene Muret Bigottini, Serv Med Interne Geriatr, F-93270 Sevran, FranceHop Rene Muret Bigottini Sevran France F-93270 r, F-93270 Sevran, France Univ Paris 13, Sevran, France Univ Paris 13 Sevran FranceUniv Paris 13, Sevran, France Inst Med Legal Paris, Paris, France Inst Med Legal Paris Paris FranceInst Med Legal Paris, Paris, France Univ Paris 05, Fac Med Cochin Port Royal, Dept Med Legale, Paris, France Univ Paris 05 Paris France n Port Royal, Dept Med Legale, Paris, France INSERM, Inst Federat Rech Circulat Lariboisiere, Paris, France INSERM Paris France t Federat Rech Circulat Lariboisiere, Paris, France
Titolo Testata:
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
fascicolo: 11, volume: 56, anno: 2001,
pagine: M719 - M723
SICI:
1079-5006(200111)56:11<M719:AAGEOC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; RAT CARDIAC MYOCYTES; AGING RAT; CARDIOVASCULAR-DISEASE; CELLULAR HYPERTROPHY; GEL-ELECTROPHORESIS; MECHANISMS; EXPRESSION; FAILURE; PROTOONCOGENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Belmin, JL Hop Rene Muret Bigottini, Serv Med Interne Geriatr, F-93270 Sevran, France Hop Rene Muret Bigottini Sevran France F-93270 Sevran, France
Citazione:
Z. Mallat et al., "Age and gender effects on cardiomyocyte apoptosis in the normal human heart", J GERONT A, 56(11), 2001, pp. M719-M723

Abstract

Background. Animal studies have suggested that apoptosis could play a significant role in the myocardial aging process. Although no information is available in humans, the paradigm that cardiomyocyte apoptosis is increased in the aged human heart has been widely propagated. Moreover, it is unknown whether gender differences may influence cardiomyocyte apoptosis. Methods. Cardiomyocyte apoptosis was compared between subjects ranging in age from 21 to 93 years (22 men and 19 women), free of any cardiovascular disease, who died of either violent or natural causes. Strict inclusion and exclusion criteria were used to ensure that the selected hearts accurately represented normal aging. Results. Apoptosis was detected using the TdT-mediated dUTP digoxigenin nick end labeling (TUNEL) technique go (controls for TUNEL included negative staining for splicing factor SC-35 and for Ki-67 antigen). The percentage of cardiomyocyte death ranged from 0% to 0.0437%, with no correlation with the age of the subject (p =.85). However, the percentage of apoptosis was threefold higher in men than in women (0.0133% +/- 0.0030% vs 0.0042% +/- 0.0008%, respectively; P < .01). Conclusions. Our results in humans do not support the hypothesis that aging influences the percentage of cardiomyocyte apoptosis. However, gender appears to be an important determinant of the occurrence of apoptosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:18:21