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Titolo:
Apoptosis and aging: Role of the mitochondria
Autore:
Pollack, M; Leeuwenburgh, C;
Indirizzi:
Univ Florida, Biochem Aging Lab, Coll Hlth & Human Performance, Gainesville, FL 32611 USA Univ Florida Gainesville FL USA 32611 formance, Gainesville, FL 32611 USA
Titolo Testata:
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
fascicolo: 11, volume: 56, anno: 2001,
pagine: B475 - B482
SICI:
1079-5006(200111)56:11<B475:AAAROT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERMEABILITY TRANSITION PORE; FREE-RADICAL THEORY; HUMAN SUBSTANTIA-NIGRA; RENAL MESANGIAL CELLS; NITRIC-OXIDE; CYTOCHROME-C; OXIDATIVE STRESS; UP-REGULATION; LIFE-SPAN; BCL-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
97
Recensione:
Indirizzi per estratti:
Indirizzo: Leeuwenburgh, C Univ Florida, Biochem Aging Lab, Coll Hlth & Human Performance, 25 FLG,Stadium Rd,POB 118206, Gainesville, FL 32611 USA Univ Florida 25 FLG,Stadium Rd,POB 118206 Gainesville FL USA 32611
Citazione:
M. Pollack e C. Leeuwenburgh, "Apoptosis and aging: Role of the mitochondria", J GERONT A, 56(11), 2001, pp. B475-B482

Abstract

Apoptosis research is a rapidly developing area, but the role of apoptosisis still unclear and controversial. For example, several studies document a significant loss of cardiac and skeletal myocytes during normal aging, possibly by apoptotic mechanisms. This loss in cells may be directly mediatedby mitochondrial dysfunction caused by chronic exposure to oxidants and increased activation of mitochondrial permeability transition pores. This review will discuss apoptosis in the context of normal aging of T cells, cardiac myocytes, skeletal muscle, and brain cortex. Particular attention is paid to the role of the mitochondria, because they have been implicated as a major control center regulating apoptosis. Mitochondrial oxidative stress and a decline in mitochondrial energy production in vitro often leads to activation of apoptotic pathways, but whether this occurs in vivo is unclear.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:20:08