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Titolo:
Estrogen, progesterone, and androgen receptor expression in levator ani muscle and fascia
Autore:
Copas, P; Bukovsky, A; Asbury, B; Elder, RF; Caudle, MR;
Indirizzi:
Univ Tennessee, Grad Sch Med, Dept Obstet & Gynecol, Knoxville, TN 37920 USA Univ Tennessee Knoxville TN USA 37920 & Gynecol, Knoxville, TN 37920 USA Univ Tennessee, Grad Sch Med, Lab Dev Differentiat & Canc, Knoxville, TN 37920 USA Univ Tennessee Knoxville TN USA 37920 iat & Canc, Knoxville, TN 37920 USA
Titolo Testata:
JOURNAL OF WOMENS HEALTH & GENDER-BASED MEDICINE
fascicolo: 8, volume: 10, anno: 2001,
pagine: 785 - 795
SICI:
1524-6094(200110)10:8<785:EPAARE>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-REPLACEMENT THERAPY; STRESS URINARY-INCONTINENCE; PELVIC FLOOR MUSCLES; POSTMENOPAUSAL WOMEN; VAGINA; TRACT; PATHOGENESIS; ANTIBODIES; TRANSITION; SPHINCTER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Bukovsky, A Univ Tennessee, Grad Sch Med, Dept Obstet & Gynecol, 1924 Alcoa Highway, Knoxville, TN 37920 USA Univ Tennessee 1924 Alcoa Highway Knoxville TN USA 37920 0 USA
Citazione:
P. Copas et al., "Estrogen, progesterone, and androgen receptor expression in levator ani muscle and fascia", J WOMEN H G, 10(8), 2001, pp. 785-795

Abstract

Previous studies have reported controversial data on estrogen receptor (ER) expression in levator ani muscle. We investigated ER expression in levator ani muscle and fascia and compared it with the expression of progesteronereceptor (PR) and androgen receptor (AR). The study included 55 women undergoing surgery for gynecological (asymptomatic, n = 10) or urogynecologicalconditions (symptomatic, n = 45). The asymptomatic and 21 of the symptomatic women received no hormone replacement therapy (HRT). The remaining 24 symptomatic women received some form of HRT. Biopsies were taken from the levator ani muscle and the overlying fascia, and quantitative measurements of immunohistochemical staining by image analysis were made. None of the levator ani muscle samples showed any evidence of nuclear ER expression in striated muscle fibers, but some cells in the muscular stroma did express ER. However, PR and AR expression was found in both muscle and stromal cells. Levator ani fascia showed nuclear ER, PR, and AR expression to varying degrees. There was a significant increase (p<0.03) in ER expression in levator anifascia of symptomatic patients without HRT when compared with asymptomaticage-matched women. The ER expression was significantly lower (p<0.001) in postmenopausal symptomatic women receiving longterm estrogen replacement compared with age-matched women without HRT. Our data indicate that ER expression is significantly higher in symptomatic women compared with age-matchedasymptomatic females. However, long-term estrogenization causes significant decrease of ER expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 22:10:36