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Titolo:
DEET (N,N-diethyl-m-toluamide) alone and in combination with permethrin increased urinary excretion of 6 beta-hydroxycortisol in rats, a marker of hepatic CYP3A induction
Autore:
Abu-Qare, AW; Abou-Donia, MB;
Indirizzi:
Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Pharmacol & Canc Biol, Durham, NC 27710 USA
Titolo Testata:
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
fascicolo: 5, volume: 64, anno: 2001,
pagine: 373 - 384
SICI:
1528-7394(20011109)64:5<373:D(AAIC>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; PYRIDOSTIGMINE BROMIDE; FREE CORTISOL; GULF-WAR; TOXIC ENCEPHALOPATHY; INSECT REPELLENTS; MASS-SPECTROMETRY; IN-VIVO; METABOLISM; EXPOSURES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Abou-Donia, MB Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 c Biol, Durham, NC 27710 USA
Citazione:
A.W. Abu-Qare e M.B. Abou-Donia, "DEET (N,N-diethyl-m-toluamide) alone and in combination with permethrin increased urinary excretion of 6 beta-hydroxycortisol in rats, a marker of hepatic CYP3A induction", J TOX E H A, 64(5), 2001, pp. 373-384

Abstract

In this study, the ratio of 6 beta -hydroxycortisol (6 beta -OHF) to free cortisol (F) was determined in urine following a single dermal dose of 400 mg/kg of DEET (N,N-diethyl-m-toluamide), and 1.3 mg/kg of permethrin, aloneand in combination, in rats. Urine samples were collected at 2, 4, 8, 16, 24, 48, and 72 h after application. Recoveries of 6 beta -OHF and cortisol (F) from control urine samples were between 75 and 85%, with limits of detection at 30 and 10 ng/ml for cortisol and 6 beta -OHF, respectively. A single dermal dose of DEET alone and in combination with permethrin significantly increased urinary excretion of 6 beta -hydroxycortisol 24 h after dosing. Permethrin did not significantly alter the urinary excretion of 6 beta -hydroxycortisol. These results indicate that DEET, alone and in combination with permethrin, increased urinary excretion of 6 beta -OHF in rats following a single dermal dose application.

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Documento generato il 27/05/20 alle ore 14:59:18