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Titolo:
Long-term administration of amlodipine prevents decompensation to diastolic heart failure in hypertensive rats
Autore:
Nishikawa, N; Masuyama, T; Yamamoto, K; Sakata, Y; Mano, T; Miwa, T; Sugawara, M; Hori, M;
Indirizzi:
Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut A8, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 peut A8, Suita, Osaka 5650871, Japan Osaka Univ, Genome Informat Res Ctr, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 Res Ctr, Suita, Osaka 5650871, Japan Tokyo Womens Med Univ, Dept Cardiovasc Sci, Tokyo, Japan Tokyo Womens Med Univ Tokyo Japan iv, Dept Cardiovasc Sci, Tokyo, Japan
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 5, volume: 38, anno: 2001,
pagine: 1539 - 1545
SICI:
0735-1097(20011101)38:5<1539:LAOAPD>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
DILATED CARDIOMYOPATHY; CARDIAC INTERSTITIUM; RENIN-ANGIOTENSIN; COLLAGEN; HYPERTROPHY; DISEASE; PHENOTYPES; NIFEDIPINE; PREVALENCE; MORTALITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Masuyama, T Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut A8, 2-2 Yamadaoka,Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 0871, Japan
Citazione:
N. Nishikawa et al., "Long-term administration of amlodipine prevents decompensation to diastolic heart failure in hypertensive rats", J AM COL C, 38(5), 2001, pp. 1539-1545

Abstract

OBJECTIVES We assessed the effects of long-term amlodipine administration in a diastolic heart failure (DHF) rat model with preserved systolic function as well as the relationship between changes in left ventricular (LV) myocardial stiffening and alterations in extracellular matrix. BACKGROUND Although the effect of long-term administration of amlodipine has been shown to be disappointing in patients with systolic failure, the effect is unknown in those with DHF. METHODS Dahl salt-sensitive rats fed a high-salt diet for seven weeks weredivided into three groups: eight untreated rats (DHF group), eight rats given high-dose amlodipine (10 mg/kg/day,; HDA group) and seven rats given low-dose amlodipine (1 mg/kg/day; LDA group). RESULTS High-dose administration of amlodipine decreased systolic blood pressure and controlled excessive hypertrophy, without a decrease in the collagen content, and prevented the elevation of LV end-diastolic pressure at 19 weeks. Low-dose administration of amlodipine with subdeppressive effects did not control either hypertrophy or fibrosis; however, it prevented myocardial stiffening and, hence, the elevation of LV end-diastolic pressure. The ratio of type I to type III collagen messenger ribonucleic acid levels was significantly, lower in both the HDA and LDA groups than in the DHF group. CONCLUSIONS Long-term administration of amlodipine prevented the transition, to DHF both at the depressor and subdepressor doses. Amlodipine did not decrease the collagen content, but attenuated myocardial stiffness, with inhibition of the phenotype shift from type III to type I collagen. Thus, amlodipine may exert beneficial effects through amelioration of collagen remodeling in the treatment of DHF. (J Am Coll Cardiol 2001;38:1539-45) (C) 2001by, the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 04:04:13