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Titolo:
An inhibitor of inducible nitric oxide synthase decreases forearm blood flow in patients with congestive heart failure
Autore:
Ishibashi, Y; Shimada, T; Murakami, Y; Takahashi, N; Sakane, T; Sugamori, T; Ohata, S; Inoue, S; Ohta, Y; Nakamura, K; Shimizu, H; Katoh, H; Hashimoto, M;
Indirizzi:
Shimane Med Univ, Dept Internal Med 4, Izumo, Shimane 6938501, Japan Shimane Med Univ Izumo Shimane Japan 6938501 zumo, Shimane 6938501, Japan Shimane Med Univ, Dept Physiol, Izumo, Shimane 693, Japan Shimane Med Univ Izumo Shimane Japan 693 ysiol, Izumo, Shimane 693, Japan
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 5, volume: 38, anno: 2001,
pagine: 1470 - 1476
SICI:
0735-1097(20011101)38:5<1470:AIOINO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; BASAL VASOMOTOR TONE; SKELETAL-MUSCLE; VIRAL MYOCARDITIS; MURINE MODEL; EXPRESSION; VASODILATION; AMINOGUANIDINE; CARDIOMYOPATHY; MECHANISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Ishibashi, Y Shimane Med Univ, Dept Internal Med 4, 89-1 Enyacho, Izumo, Shimane 6938501, Japan Shimane Med Univ 89-1 Enyacho Izumo Shimane Japan 6938501 pan
Citazione:
Y. Ishibashi et al., "An inhibitor of inducible nitric oxide synthase decreases forearm blood flow in patients with congestive heart failure", J AM COL C, 38(5), 2001, pp. 1470-1476

Abstract

OBJECTIVES The functional activation of inducible nitric oxide synthase (iNOS) was evaluated as a source of nitric oxide (NO) in the forearm of patients with heart failure. BACKGROUND Although endogenous NO is normally produced by constitutive NO synthase (cNOS) in patients with congestive heart failure (CHF), expressionof iNOS provides an additional source of NO. However, there are no in vivostudies showing functional activation of iNOS in humans. METHODS A nonselective NOS inhibitor, N-G-monomethyl-L-arginine (L-NMMA), and a selective inhibitor of iNOS, aminoguanidine, were administered intra-arterially in graded doses into the brachial arteries of 13 patients with CHF and 10 normal control subjects. Forearm blood flow (FBF) was measured simultaneously in the infused and noninfused arms by plethysmography. Arterial and venous plasma concentrations of nitrite/nitrate (NOx) were measured at baseline and at the highest dose of each drug. RESULTS L-NMMA significantly reduced the FBF ratio between the infused andnoninfused arms in both the control and patient groups (35 +/- 12% and 34 /- 10%, respectively; both p < 0.001). Aminoguanidine at the same concentration significantly reduced the ratio in the patient group (15 +/- 9%, p < 0.01), with no change in the control group. The arterial NOx concentration was not affected by either drug; however, venous NOx concentrations were significantly decreased in both the control and patient groups by L-NMMA (18 /- 5% and 18 +/- 17%, respectively; both p < 0.05) and in the patient group only by aminoguanidine (7 +/- 6%, p < 0.05). CONCLUSIONS These findings suggest that NO production in the forearms of patients with CHF is induced partly by iNOS activation, whereas in normal subjects, it can be ascribed to cNOS activation. (J Am Coll Cardiol 2001;38:1470-6) (C) 2001 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 15:38:26