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Titolo:
Pressure-derived collateral flow index as a parameter of microvascular dysfunction in acute myocardial infarction
Autore:
Yamamoto, K; Ito, H; Iwakura, K; Shintani, Y; Masuyama, T; Hori, M; Kawano, S; Higashino, Y; Fujii, K;
Indirizzi:
Sakurabashi Watanabe Hosp, Div Cardiol, Kita Ku, Osaka 5300001, Japan Sakurabashi Watanabe Hosp Osaka Japan 5300001 a Ku, Osaka 5300001, Japan Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut, Osaka, Japan Osaka Univ Osaka Japan Med, Dept Internal Med & Therapeut, Osaka, Japan
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 5, volume: 38, anno: 2001,
pagine: 1383 - 1389
SICI:
0735-1097(20011101)38:5<1383:PCFIAA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NO-REFLOW PHENOMENON; CORONARY ANGIOPLASTY; TIMI TRIAL; BLOOD-FLOW; PHASE-I; THROMBOLYSIS; ARTERY; PREDICTOR; STENOSIS; HUMANS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Ito, H Sakurabashi Watanabe Hosp, Div Cardiol, Kita Ku, 2-4-32 Umeda, Osaka 5300001, Japan Sakurabashi Watanabe Hosp 2-4-32 Umeda Osaka Japan 5300001 , Japan
Citazione:
K. Yamamoto et al., "Pressure-derived collateral flow index as a parameter of microvascular dysfunction in acute myocardial infarction", J AM COL C, 38(5), 2001, pp. 1383-1389

Abstract

Objectives The goal of this study was to examine the implications of the pressure-derived collateral flow index (CFIp) in acute myocardial infarction(AMI). Background Higher CFIp is associated with less severe myocardial ischemia during angioplasty in the non-infarcted heart. It remains unknown whether CFIp also identifies collateral function in AMI patients with and without no-reflow phenomenon. Methods The study population included 48 patients with a first AMI. After successful percutaneous transluminal coronary, angioplasty (PTCA) stent, wemeasured mean aortic pressure (Pa), central venous pressure (Pv) and coronary wedge pressure (Pew) of the infarct-related artery to calculate: CFIp =(Pcw - Pv)/(Pa - Pv). Myocardial contrast echocardiography (MCE) was performed with the intracoronary, injection of microbubbles to assess myocardialperfusion. Left ventriculograms at days 1 and 28 were provided for the measurement of the regional wall motion (RWM, SD/chord). Results There was no difference in CFIp among subsets based on angiographic collateral grades (grade 0, 1, 2, 3; 0.28 +/-0.07, 0.27 +/-0.09, 0.27 +/-0.08, 0.23 +/-0.08, p=NS). The CFIp was significantly higher in patients with NICE no-reflow (n=16) than in those with MCE reflow (n=32) (0.34 +/-0.07vs. 0.23 +/-0.06, p<0.01). There was a significant inverse correlation between the extent of functional improvement (<Delta>RWM[28 d-1 d]) and CFIp (r=0.56, p<0.01), implying that higher CFIp is associated with worse functional improvement. Conclusions In AMI, CFIp is unlikely to reflect collateral function but seems to increase with the severity of microvascular dysfunction. Because higher CFIp was associated with poorer functional recovery, it provides a simple and useful estimate of clinical outcomes in AMI. (J Am Coll Cardiol 2001;38:1383-9) (C) 2001 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 00:04:48