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Titolo:
Increased intimal apoptosis in coronary atherosclerotic vessel segments lacking compensatory enlargement
Autore:
Hassan, AHM; Lang, IM; Ignatescu, M; Ullrich, R; Bonderman, D; Wexberg, P; Weidinger, F; Glogar, HD;
Indirizzi:
Univ Vienna, Dept Cardiol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 , Dept Cardiol, A-1090 Vienna, Austria Univ Vienna, Dept Pathol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 a, Dept Pathol, A-1090 Vienna, Austria
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 5, volume: 38, anno: 2001,
pagine: 1333 - 1339
SICI:
0735-1097(20011101)38:5<1333:IIAICA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR INHIBITOR; SMOOTH-MUSCLE CELLS; INTRAVASCULAR ULTRASOUND; ENDOTHELIAL-CELLS; VASCULAR INJURY; ANGIOPLASTY; ARTERIES; RABBIT; EXPRESSION; RESTENOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Lang, IM Univ Vienna, Allgemeines Krankenhaus, Div Cardiol, Wahringer Gurtel 18-20,A-1090 Vienna, Austria Univ Vienna Wahringer Gurtel 18-20 Vienna Austria A-1090 Austria
Citazione:
A.H.M. Hassan et al., "Increased intimal apoptosis in coronary atherosclerotic vessel segments lacking compensatory enlargement", J AM COL C, 38(5), 2001, pp. 1333-1339

Abstract

Objectives In a histopathologic study, we. assessed the balance of cell proliferation and apoptosis by counting the number of apoptotic and proliferating cell nuclear antigen-positive cells in freshly harvested atherectomy specimens from 34 patients. Background Remodeling of human coronary, arteries is an adaptive process that alters vascular lumen size. Methods Intravascular ultrasound was performed prior to atherectomy. Totalvessel area (area within the external elastic lamina [EEL]), lumen area and plaque area were measured at the region of interest (ROI), and at a proximal and distal reference segment, utilizing the formula Delta(%) = 100 x (ROI-reference segment)/reference segment. Positive arterial remodeling (R+) resulting in luminal expansion was defined as Delta EEL >10%. Absence of remodeling (0 < <Delta>EEL <10%) and constrictive arterial remodeling (<Delta>EEL <0) were considered as neutral remodeling (R0) and negative remodeling(R-), respectively. Results In R- lesions, apoptotic indices (APO) were significantly elevated(17.17<plus/minus>2.19%) compared with R+ lesions (4.89 +/-1.7%; p=0.0007). In a rabbit iliac percutaneous transluminal coronary angioplasty model intimal. apoptosis was increased four weeks after balloon angioplasty injury (APO 8.8 +/-0.03%) compared with contralateral untreated segments (APO 3.0 /-0.04%, n=6). Lesions with an EEL/intimal area <3.0 showed significantly more intimal apoptosis than untreated lesions (p=0.02). Conclusions The data indicate that constrictive remodeling of atherosclerotic coronary lesions is associated with increased apoptosis of intimal cells. We speculate that increased apoptosis is due to extensive plaque healingafter episodes of symptomatic or asymptomatic plaque rupture, (J Am Coll Cardiol 2001;38:1333-9) (C) 2001 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:50:51