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Titolo:
Flow-mediated vasodilation of the femoral and brachial artery induced by exercise in healthy nonsmoking and smoking men
Autore:
Gaenzer, H; Neumayr, G; Marschang, P; Strum, W; Kirchmair, R; Patsch, JR;
Indirizzi:
Innsbruck Univ, Dept Internal Med, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 l Med, A-6020 Innsbruck, Austria
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 5, volume: 38, anno: 2001,
pagine: 1313 - 1319
SICI:
0735-1097(20011101)38:5<1313:FVOTFA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT VASODILATATION; NITRIC-OXIDE; BLOOD-FLOW; CIGARETTE-SMOKING; CARDIOVASCULAR-DISEASE; YOUNG ADULTS; TIME-COURSE; MUSCLE; HUMANS; DYSFUNCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Gaenzer, H Innsbruck Univ, Dept Internal Med, Anichstr 35, A-6020 Innsbruck, Austria Innsbruck Univ Anichstr 35 Innsbruck Austria A-6020 k, Austria
Citazione:
H. Gaenzer et al., "Flow-mediated vasodilation of the femoral and brachial artery induced by exercise in healthy nonsmoking and smoking men", J AM COL C, 38(5), 2001, pp. 1313-1319

Abstract

Objectives We sought to analyze diameter changes of conduit arteries in response to whole-body exercise and hypothesized that this response might be endothelium-dependent and, therefore, impaired in smokers. Background Hyperemia and coincident vasodilation are pivotal mechanisms for meeting the increased metabolic demands of active muscle tissue during physical exercise, but studies in humans are sparse. Methods We studied diameter and blood flow of the femoral and brachial arteries in response to a submaximal bicycle exercise test in 10 nonsmoking and 8 smoking healthy male subjects. During an exercise period of 40 min the investigated conduit arteries were periodically scanned in longitudinal sections by high-resolution ultrasound. In the same subjects flow-mediated dilation (FMD) of the brachial artery was recorded by inducing an ischemia through a forearm-occluding cuff. Results In response to exercise the diameter of the femoral artery significantly increased in both nonsmokers and smokers, with a diminished responsein smokers (9.2 +/-1.9% vs. 4.8 +/-1.6%, p<0.001). Flow-mediated dilation of the brachial artery induced by forearm occlusion was also reduced in smoking subjects, revealing a strong correlation between these different methods of FMD (exercise vs. forearm ischemia) (r=0.88, p<0.001). In contrast, blood flow increase of the femoral artery was similar in nonsmoking and smoking subjects (392 +/- 77% vs. 382 +/- 109%, p=NS). Conclusions Conduit arteries react with a flow-mediated dilation in response to whole-body exercise. The impairment of this vasodilation observed in smokers was strongly related to a decrease of endothelium-dependent dilation induced by forearm ischemia, indicating that endothelial. dysfunction represents the underlying mechanism. (J Am Coll Cardiol 2001;38: 1313-9) (C) 2001 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:43:35