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Titolo:
Influence of clinical features, serum antinuclear antibodies, and lung function on survival of patients with systemic sclerosis
Autore:
Jacobsen, S; Ullman, S; Shen, GQ; Wiik, A; Halberg, P;
Indirizzi:
Copenhagen Univ Hosp, Hvidovre Hosp, Dept Rheumatol, Rheumatol Res Unit, DK-2650 Hvidovre, Denmark Copenhagen Univ Hosp Hvidovre Denmark DK-2650 DK-2650 Hvidovre, Denmark Copenhagen Univ Hosp, Bispebjerg Hosp, Dept Dermatol, DK-2650 Hvidovre, Denmark Copenhagen Univ Hosp Hvidovre Denmark DK-2650 DK-2650 Hvidovre, Denmark State Serum Inst, Dept Autoimmunol, Copenhagen, Denmark State Serum Inst Copenhagen Denmark pt Autoimmunol, Copenhagen, Denmark Specialty Labs, Santa Monica, CA USA Specialty Labs Santa Monica CA USASpecialty Labs, Santa Monica, CA USA
Titolo Testata:
JOURNAL OF RHEUMATOLOGY
fascicolo: 11, volume: 28, anno: 2001,
pagine: 2454 - 2459
SICI:
0315-162X(200111)28:11<2454:IOCFSA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
RNA POLYMERASE-III; DANISH PATIENTS; CALF THYMUS; SCLERODERMA; MORTALITY; DISEASE; CLASSIFICATION; AUTOANTIBODIES; TRANSCRIPTION; PURIFICATION;
Keywords:
systemic sclerosis; prognosis; anti-RNA polymerase antibodies; anti-topoisomerase I antibodies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Jacobsen, S Copenhagen Univ Hosp, Hvidovre Hosp, Dept Rheumatol, RheumatolRes Unit, Kettegaard Alle 30, DK-2650 Hvidovre, Denmark Copenhagen Univ Hosp Kettegaard Alle 30 Hvidovre Denmark DK-2650
Citazione:
S. Jacobsen et al., "Influence of clinical features, serum antinuclear antibodies, and lung function on survival of patients with systemic sclerosis", J RHEUMATOL, 28(11), 2001, pp. 2454-2459

Abstract

Objective. To evaluate the independent contribution of several clinical and laboratory variables to the mortality of a cohort of Danish patients withsystemic sclerosis (SSc). Methods. A cohort of 174 patients with incident SSc was retrospectively identified using clinical charts and study records of all new patients with SSc. Disease onset was defined as the time of onset of cutaneous sclerosis. Vital status and causes of death were determined at the end of the observation period. Data on clinical status and pulmonary function were obtained. Antitopoisomerase I (anti-topo I), anticentromere, anti-U1-RNP, anti-U3-RNP,anti-Th-RNP and anti-RNA polymerase (anti-RNAP) antibodies were determinedby means of double immunodiffusion, immunofluorescence, hemagglutination technique, radioactively labelled antisense riboprobes. and ELISA. respectively. Results. Patients were followed for a mean period of 13.3 yrs; 16 died of an SSc related condition and 50 of other causes. Pulmonary fibrosis, DLCO reduction < 40% of the expected, diffuse cutaneous involvement. SSc nephropathy, cardiac disease. and anti-topo I and anti-RNA-P antibody were related to decreased survival due to SSc. Variables that entered a Cox regression model of SSc related mortality were right heart failure (RR 12.4. 95% CI 2.5-60), diffuse SSc (RR 7.8, 95% CI 1.8-35). SSc nephropathy (RR 6.1, 95% CI 1.8-21), and DLCO < 40% (RR 4.8. 95% CI 1.1-20). The relative risk of developing right heart failure and diffuse SSc given the presence of anti-RNAP antibody was 14 (p = 0.0001) and 1.9 (p = 0.01), respectively. The corresponding figures for anti-topo I antibody were 4.6 (p = 0.02) and 2.0 (p = 0.01). Conclusion. SSc related mortality was associated with right heart failure and diffuse SSc, both of which were also associated with the presence of anti-topo I and anti-RNAP antibody. The prognostic value of these autoantibodies may lie in the early course of the disease when specific morbidity has not yet evolved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 21:46:17