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Titolo:
Assessment of motor behavior using a video system and a clinical rating scale in parkinsonian monkeys lesioned by MPTP
Autore:
Chassain, C; Eschalier, A; Durif, F;
Indirizzi:
Fac Med & Pharm, INSERM, U9904, EMI, F-63003 Clermont Ferrand, France Fac Med & Pharm Clermont Ferrand France F-63003 Clermont Ferrand, France
Titolo Testata:
JOURNAL OF NEUROSCIENCE METHODS
fascicolo: 1, volume: 111, anno: 2001,
pagine: 9 - 16
SICI:
0165-0270(20011015)111:1<9:AOMBUA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPA-INDUCED DYSKINESIA; PRIMATE MODEL; HEMIPARKINSONIAN MONKEYS; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; AGONIST; N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; METABOLITE; SYMPTOMS; EXPOSURE; DISEASE;
Keywords:
monkey; video image analyzer system; clinical rating scales; motor behavior assessment; MPTP; levodopa;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Chassain, C Fac Med & Pharm, INSERM, U9904, EMI, Pl Henri Dunand, F-63003 Clermont Ferrand, France Fac Med & Pharm Pl Henri Dunand Clermont Ferrand France F-63003
Citazione:
C. Chassain et al., "Assessment of motor behavior using a video system and a clinical rating scale in parkinsonian monkeys lesioned by MPTP", J NEUROSC M, 111(1), 2001, pp. 9-16

Abstract

The best current model of Parkinson's disease is the primate treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Quantification of animal movement is important for the study of severity of parkinsonian syndromeinduced by MPTP and response to drug treatments. Both require clinical rating scales that measure motor behavior with well-defined objective items. However, evaluations using these scales depend on the observer scoring the different items, according to his/her experience. The video image analyzer system, which produces an activity curve in correlation with the visual study of animal motor behavior, offers an automatic evaluation method that is observer-independent and reproducible. Using such an system we defined itemscorrelated with those used in clinical rating scales that are sensitive toanimal motor changes, decrease in movements with MPTP intoxication and alleviation afforded by levodopa: global locomotor activity and specific activities (climbing, social interactions, eating and drinking behaviors). (C) 2001 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/05/20 alle ore 19:46:59