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Titolo:
Consolidation of extinction learning involves transfer from NMDA-independent to NMDA-dependent memory
Autore:
Santini, E; Muller, RU; Quirk, GJ;
Indirizzi:
Ponce Sch Med, Dept Physiol, Ponce, PR 00732 USA Ponce Sch Med Ponce PR USA 00732 h Med, Dept Physiol, Ponce, PR 00732 USA SUNY Hlth Sci Ctr, Dept Physiol, Brooklyn, NY 11203 USA SUNY Hlth Sci CtrBrooklyn NY USA 11203 t Physiol, Brooklyn, NY 11203 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 22, volume: 21, anno: 2001,
pagine: 9009 - 9017
SICI:
0270-6474(20011115)21:22<9009:COELIT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; ANTAGONIST MK-801 BLOCKS; MEDIAL PREFRONTAL CORTEX; RECEPTOR ANTAGONIST; CONDITIONAL FEAR; CENTRAL NUCLEUS; INHIBITORY AVOIDANCE; BASOLATERAL AMYGDALA; LATE-PHASE; RATS;
Keywords:
fear conditioning; medial prefrontal cortex; amygdala; spontaneous recovery; LTP; infralimbic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Quirk, GJ Ponce Sch Med, Dept Physiol, POB 7004, Ponce, PR 00732 USA PonceSch Med POB 7004 Ponce PR USA 00732 4, Ponce, PR 00732 USA
Citazione:
E. Santini et al., "Consolidation of extinction learning involves transfer from NMDA-independent to NMDA-dependent memory", J NEUROSC, 21(22), 2001, pp. 9009-9017

Abstract

Extinction of conditioned fear to a tone paired with foot shock is thoughtto involve the formation of new memory. In support of this, previous studies have shown that extinction of conditioned fear depends on NMDA receptor-mediated plasticity. To further investigate the role of NMDA receptors in extinction, we examined the effects of the NMDA antagonist D(-)-3-(2-carboxypiperazine-4-yl)-propyl-1-phosphonic acid (CPP) on the extinction of conditioned freezing and suppression of bar pressing (conditioned emotional response). Rats extinguished normally during a 90 min session in the presence ofsystemic CPP (10 mg/kg), but were unable to recall extinction learning 24 hr later. This suggests that an NMDA-independent form of plasticity supports short-term extinction memory, but NMDA receptors are required for consolidation processes leading to long-term extinction memory. Surprisingly, extinction learned in the presence of CPP was recalled normally when tested 48 hr after training, suggesting a delayed consolidation process that was ableto improve memory in the absence of further training. Delayed consolidation involves NMDA receptors because CPP injected on the rest day between training and test prevented 48 hr recall of extinction learned under CPP. Control experiments showed that the effect of CPP on memory consolidation was not caused by state-dependent learning or reduced expression of freezing under CPP. These findings demonstrate that NMDA receptor activation is criticalfor consolidation of extinction learning and that this process can be initiated after training has taken place. We suggest that consolidation of extinction involves off-line relearning that reinforces extinction memory through NMDA-mediated plasticity, perhaps in prefrontal-amygdala circuits.

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Documento generato il 06/04/20 alle ore 21:42:54