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Titolo:
Lipase enhanced catalytic efficiency in lactonisation reactions
Autore:
Bonini, C; Cazzato, C; Cernia, E; Palocci, C; Soro, S; Viggiani, L;
Indirizzi:
Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy Univ Roma LaSapienza Rome Italy I-00185 mento Chim, I-00185 Rome, Italy Univ Basilicata, Dipartimento Chim, I-85100 Potenza, Italy Univ Basilicata Potenza Italy I-85100 mento Chim, I-85100 Potenza, Italy
Titolo Testata:
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
fascicolo: 1, volume: 16, anno: 2001,
pagine: 1 - 5
SICI:
1381-1177(20011120)16:1<1:LECEIL>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HMG-COA REDUCTASE; ENANTIOSELECTIVE SYNTHESIS; ASYMMETRIC-SYNTHESIS; COMPACTIN; LACTONIZATION; INHIBITORS; ESTERS; MEVINOLIN; ANALOGS; ENZYMES;
Keywords:
lipase; lactonisation; statins; organic solvent;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Palocci, C Univ Roma La Sapienza, Dipartimento Chim, Piazzale Aldo Moro 5,I-00185 Rome, Italy Univ Roma La Sapienza Piazzale Aldo Moro 5 Rome ItalyI-00185
Citazione:
C. Bonini et al., "Lipase enhanced catalytic efficiency in lactonisation reactions", J MOL CAT B, 16(1), 2001, pp. 1-5

Abstract

We studied an enantioselective. lipase-catalysed transesterification reaction for the production of the statin lactone moiety. It is well known that the chiral cyclic structure of statins is very important for their pharmaceutical activity in the prevention and treatment of coronary artery diseases. We focused our attention on 3R,5R-6-(ethyl-2-phenyl)-4-hydroxytetrahydropyran-2-one (2); this was synthesised by employing an enantioselective lactonisation reaction catalysed by a commercial preparation of porcine pancreatic lipase (PPL) starting from a racemic mixture of syn-diol rac-1. Optimisation of the reaction conditions for the biocatalysed intramolecular transesterification reaction of the racemic diol I was carried out. It was seen that the maximal reaction rate could be greatly enhanced by the addition of solid matrices to the reaction medium. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 12:16:24