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Titolo:
Blood pressure, cardiac structure and severity of obstructive sleep apnea in a sleep clinic population
Autore:
Kraiczi, H; Peker, Y; Caidahl, K; Samuelsson, A; Hedner, J;
Indirizzi:
Sahlgrens Univ Hosp, Dept Clin Pharmacol, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp, Dept Pulm Med, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp, Dept Clin Physiol, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 S-41345 Gothenburg, Sweden
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 11, volume: 19, anno: 2001,
pagine: 2071 - 2078
SICI:
0263-6352(200111)19:11<2071:BPCSAS>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR HYPERTROPHY; CARDIOVASCULAR RISK-FACTORS; POSITIVE AIRWAY PRESSURE; ESSENTIAL-HYPERTENSION; SYSTEMIC HYPERTENSION; OBESITY; ASSOCIATION; PREVALENCE; SNORERS; SIZE;
Keywords:
ambulatory blood pressure measurement; blood pressure; cardiac size; echocardiography; obstructive sleep apnea;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Kraiczi, H Sahlgrens Univ Hosp, Dept Clin Pharmacol, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 henburg, Sweden
Citazione:
H. Kraiczi et al., "Blood pressure, cardiac structure and severity of obstructive sleep apnea in a sleep clinic population", J HYPERTENS, 19(11), 2001, pp. 2071-2078

Abstract

Objectives We investigated whether the severity of obstructive sleep apnea(OSA) predicts blood pressure or cardiac left ventricular thickness in a clinical population of OSA patients, if adjustments are made for age, gender, use of antihypertensive agents, smoking, body mass index, history of coronary artery disease, hypercholesterolemia and circulating C-peptide concentrations. Design Relationships in this cross-sectional study were investigated with correlation analysis and multiple regression procedures. Patients and methods Apnea-hypopnea index (AHI, polysomnography) and office systolic and diastolic blood pressures (SBP and DBP) were measured in 81 subjects referred to a university hospital sleep laboratory. Ambulatory blood pressures were recorded during one 24 h cycle. Left ventricular (LV) muscle size was quantified as two-dimensionally directed M-mode-derived end-diastolic thickness of interventricular septum and posterior chamber wall. Results After adjustment for separate or the entire set of covariates, AHIpredicted office SBP and DBP as well as daytime ambulatory DBP and night-time ambulatory SBP and DBP, but not daytime ambulatory SBP. In contrast, associations between AHI and LV muscle thickness reflected complex inter-relationships with confounding variables. Smoking and age suppressed, whereas body mass index (BMI) and hypertension inflated the relationship between OSAseverity and LV muscle thickness in this study. Conclusions AHI is an independent predictor of several measures of blood pressure. OSA severity and LV muscle thickness appear to be primarily linkedvia increased blood pressure. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 08:42:42