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Titolo:
Association analyses between genetic polymorphisms of endothelial nitric oxide synthase gene and hypertension in Japanese: The Suita Study
Autore:
Tsujita, Y; Baba, S; Yamauchi, R; Mannami, T; Kinoshita, M; Yamamoto, R; Katsuya, T; Higaki, J; Ogihara, T; Ogata, J; Iwai, N;
Indirizzi:
Natl Cardiovasc Ctr, Res Inst, Suita, Osaka, Japan Natl Cardiovasc Ctr Suita Osaka Japan Ctr, Res Inst, Suita, Osaka, Japan Shiga Univ Med Sci, Dept Internal Med 1, Otsu, Shiga 52021, Japan Shiga Univ Med Sci Otsu Shiga Japan 52021 Med 1, Otsu, Shiga 52021, Japan Osaka Univ, Sch Med, Dept Geriatr Med, Suita, Osaka 565, Japan Osaka UnivSuita Osaka Japan 565 ept Geriatr Med, Suita, Osaka 565, Japan
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 11, volume: 19, anno: 2001,
pagine: 1941 - 1948
SICI:
0263-6352(200111)19:11<1941:AABGPO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; RISK-FACTORS; LINKAGE; MUTATION; T-786->C; SPASM;
Keywords:
blood pressure; genetics; hypertension; nitric oxide synthase; polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Iwai, N Natl Cardiovasc Ctr, Res Inst, 5-7-1 Fujishirodai, Suita, Osaka, Japan Natl Cardiovasc Ctr 5-7-1 Fujishirodai Suita Osaka Japan a, Japan
Citazione:
Y. Tsujita et al., "Association analyses between genetic polymorphisms of endothelial nitric oxide synthase gene and hypertension in Japanese: The Suita Study", J HYPERTENS, 19(11), 2001, pp. 1941-1948

Abstract

Objectives Endothelium-derived nitric oxide plays a key role in the regulation of vascular tone. Recently, endothelial nitric oxide synthase (eNOS) gene polymorphisms were reported to be associated with hypertension or coronary spasm. We investigated the association between the eNOS gene polymorphisms and hypertension in a large population-based sample of 4055 Japanese. Design and methods We investigated two polymorphisms of the eNOS gene, Glu298Asp polymorphism of exon 7 and T(-786)C polymorphism of the promoter region. The genotype distribution in hypertensive subjects was compared to that in the other subjects. The influence of the genotype on blood pressure values was analyzed in the subjects not taking hypertensive medication. The promoter activities of the eNOS gene with the (-786)T or (-786)C allele weremeasured by a luciferase reporter gene assay. Results There was significant linkage disequilibrium between the two polymorphisms (P < 0.0001). The genotype distribution of the Glu298Asp or T(-786)C polymorphism did not differ between the hypertensive and the other subjects. No significant differences in the blood pressure of subjects not taking hypertensive medication were observed among the three genotypes of Glu298Asp or T(-786)C polymorphisms. No significant differences in the promoter activity were observed between bovine endothelial cells transfected with the(-786)T and (-786)C alleles. Conclusions Our data suggested that these polymorphisms of the eNOS gene are unlikely to be major factors in the susceptibility to hypertension in the Japanese population studied. (C) 2001 Lippincott Williams& Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 17:41:13