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Titolo:
Characterization of duplicated zebrafish cyp19 genes
Autore:
Chiang, EFL; Yan, YL; Tong, SK; Hsiao, PH; Guiguen, Y; Postlethwait, J; Chung, BC;
Indirizzi:
Acad Sinica, Inst Mol Biol, Taipei 115, Taiwan Acad Sinica Taipei Taiwan115 Sinica, Inst Mol Biol, Taipei 115, Taiwan Univ Oregon, Inst Neurosci, Eugene, OR 97403 USA Univ Oregon Eugene OR USA 97403 egon, Inst Neurosci, Eugene, OR 97403 USA Natl Taiwan Univ Hosp, Dept Pediat, Taipei 10016, Taiwan Natl Taiwan Univ Hosp Taipei Taiwan 10016 t Pediat, Taipei 10016, Taiwan INRA, SCRIBE, F-35042 Rennes, France INRA Rennes France F-35042INRA, SCRIBE, F-35042 Rennes, France
Titolo Testata:
JOURNAL OF EXPERIMENTAL ZOOLOGY
fascicolo: 7, volume: 290, anno: 2001,
pagine: 709 - 714
SICI:
0022-104X(200112)290:7<709:CODZCG>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKAGE MAP; DANIO-RERIO; GENOME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Chung, BC Acad Sinica, Inst Mol Biol, Taipei 115, Taiwan Acad Sinica Taipei Taiwan 115 nst Mol Biol, Taipei 115, Taiwan
Citazione:
E.F.L. Chiang et al., "Characterization of duplicated zebrafish cyp19 genes", J EXP ZOOL, 290(7), 2001, pp. 709-714

Abstract

The zebrafish has recently been developed as a good genetic model system. We report here the use of zebrafish to study the regulation of estrogen biosynthesis. The CYP19 gene encodes cytochrome P450 aromatase, which catalyzes the synthesis of estrogens. Two cyp19 genes, termed cyp19a and cyp19b, have been isolated from zebrafish. Sequence comparison shows that Cyp19a and Cyp19b belong to two separate Cyp19 subfamilies. The cyp19a gene is expressed in the ovary, whereas cyp19b is expressed in the brain. The cyp19a and cyp19b genes are located on zebrafish chromosomes LG 18 and 25, respectively. Our data indicate that these gene loci arose through an ancient chromosomal duplication event. The expression of duplicated genes in distinct tissues may have evolutionary significance. J. Exp. Zool. 290:709-714, 2001. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 30/03/20 alle ore 09:48:50