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Titolo:
Restenosis after percutaneous transluminal angioplasty in the femoropopliteal segment: The role of inflammation
Autore:
Schillinger, M; Haumer, M; Schlerka, G; Mlekusch, W; Exner, M; Ahmadi, R; Minar, E;
Indirizzi:
Univ Vienna, Sch Med, Dept Angiol, Vienna, Austria Univ Vienna Vienna Austria ienna, Sch Med, Dept Angiol, Vienna, Austria Univ Vienna, Sch Med, Dept Lab Med, Vienna, Austria Univ Vienna Vienna Austria enna, Sch Med, Dept Lab Med, Vienna, Austria
Titolo Testata:
JOURNAL OF ENDOVASCULAR THERAPY
fascicolo: 5, volume: 8, anno: 2001,
pagine: 477 - 483
SICI:
1526-6028(200110)8:5<477:RAPTAI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-REACTIVE PROTEIN; ABDOMINAL AORTIC-ANEURYSMS; ARTERIAL OCCLUSIVE DISEASE; TRANS-LUMINAL ANGIOPLASTY; SEVERE UNSTABLE ANGINA; CORONARY ANGIOPLASTY; PERIPHERAL ARTERIES; RISK-FACTORS; FOLLOW-UP; ASSOCIATION;
Keywords:
C-reactive protein; hemodynamics; patency; acute-phase reactants;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Schillinger, M Gen Hosp, Sch Med, Dept Internal Med 2, Wahringer Gurtel 18-20-6J, A-1090 Vienna, Austria Gen Hosp Wahringer Gurtel 18-20-6J Vienna Austria A-1090 a
Citazione:
M. Schillinger et al., "Restenosis after percutaneous transluminal angioplasty in the femoropopliteal segment: The role of inflammation", J ENDOVAS T, 8(5), 2001, pp. 477-483

Abstract

Purpose: To determine the value of baseline C-reactive protein (CPR), fibrinogen, and white blood cell (WBC) counts in predicting 1-year patency after percutaneous transluminal angioplasty (PTA) in the femoropopliteal segment. Methods: In a retrospective cohort study, 168 consecutive patients (103 men; median age 70 years, interquartile range 61-77) who underwent successfulPTA of the femoral and/or popliteal arteries were analyzed. Twelve-month patency was evaluated using oscillography, ankle brachial index, duplex sonography, and angiography. The predictive value of inflammatory markers was assessed in a multivariate model controlling for cardiovascular risk factors, technical success, and hemodynamic factors. Results: Transient WBC elevation was found 6 hours after PTA, but this returned to baseline after 24 hours. Fibrinogen was elevated at 24 hours. Duplex scanning disclosed restenosis in 66 (39%) patients within the first 12 months after PTA. Only residual postdilation stenosis (greater than or equalto 30%) in the target segment (odds ratio 3.6, p = 0.001) and baseline CRPlevels (odds ratio 4.2, p = 0.02) were independent predictors of outcome; neither WBC counts nor fibrinogen levels at any time point was associated with restenosis. Conclusions. Primary technical success and postinterventional hemodynamic flow at the dilated segment seem to be more important for intermediate-termpatency than atherogenic risk factors. The predictive value of preprocedural serum CRP levels on restenosis should be further investigated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/12/19 alle ore 14:56:16