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Titolo:
Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with restenosis after percutaneous transluminal angioplasty
Autore:
Exner, M; Schillinger, M; Minar, E; Mlekusch, W; Schlerka, G; Haumer, M; Mannhalter, C; Wagner, O;
Indirizzi:
Univ Vienna, Sch Med, Dept Lab Med, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 , Dept Lab Med, A-1090 Vienna, Austria Univ Vienna, Sch Med, Dept Angiol, Vienna, Austria Univ Vienna Vienna Austria ienna, Sch Med, Dept Angiol, Vienna, Austria
Titolo Testata:
JOURNAL OF ENDOVASCULAR THERAPY
fascicolo: 5, volume: 8, anno: 2001,
pagine: 433 - 440
SICI:
1526-6028(200110)8:5<433:HOGPMP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; TRANS-LUMINAL ANGIOPLASTY; CARBON-MONOXIDE; PROTECTIVE GENES; EXPRESSION; ARTERIES; ATHEROSCLEROSIS; INJURY; SUSCEPTIBILITY; PROLIFERATION;
Keywords:
gene polymorphism; GT dinucleotide repeats; smooth muscle cells; vascular remodeling; intimal hyperplasia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Wagner, O Univ Vienna, Sch Med, Dept Lab Med, Waehringer Guertel 18-20, A-1090 Vienna, Austria Univ Vienna Waehringer Guertel 18-20 Vienna Austria A-1090 tria
Citazione:
M. Exner et al., "Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with restenosis after percutaneous transluminal angioplasty", J ENDOVAS T, 8(5), 2001, pp. 433-440

Abstract

Purpose: To determine if an association exists between postdilation restenosis and heme oxygenase-1 (HO-1), which is Induced by balloon injury and inhibits neointimal formation through the action of endogenous carbon monoxide. A dinucleotide repeat in the promoter region of the HO-1 gene shows a length polymorphism that modulates the level of gene transcription. Methods: This cohort study included 96 consecutive patients (64 men; median age 69 years, interquartile range 60-75) who underwent successful balloondilation in the femoropopliteal segment. Six-month patency was evaluated using oscillography, ankle-brachial index, and duplex sonography. The association of patency and the length of (GT) repeats in the HO-1 gene promoter was assessed in univariate and multivariate analyses. Results: Restenosis was found in 23 (24%) patients within the first 6 months. Patients with short (< 25 GT) dinucleotide repeats in the HO-1 gene promoter on either allele had restenosis. significantly less often than patients with longer ( greater than or equal to 25 GT) dinucleotide repeats (p = 0.01). Multivariate analysis revealed a significantly reduced risk for restenosis in these patients compared to patients without the short allele (odds ratio 0.2, 95% Cl 0.06 to 0.70, p = 0.007). Conclusions: Genetic risk factors for restenosis after percutaneous transluminal angioplasty have not been investigated. In this patient population, short repeat alleles of the heme oxygenase-1 gene promoter polymorphism were associated with reduced postdilation restenosis at 6 months. Upregulationof HO-1 may be an important protective factor after balloon angioplasty byinhibition of vascular smooth muscle cell proliferation.

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Documento generato il 09/04/20 alle ore 10:56:05