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Titolo:
Nuclear localization of beta-catenin in the hair matrix cells and differentiated keratinocytes
Autore:
Tsuji, H; Ishida-Yamamoto, A; Takahashi, H; Iizuka, H;
Indirizzi:
Asahikawa Med Coll, Dept Dermatol, Asahikawa, Hokkaido 0788510, Japan Asahikawa Med Coll Asahikawa Hokkaido Japan 0788510 kkaido 0788510, Japan
Titolo Testata:
JOURNAL OF DERMATOLOGICAL SCIENCE
fascicolo: 3, volume: 27, anno: 2001,
pagine: 170 - 177
SICI:
0923-1811(200111)27:3<170:NLOBIT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION FACTOR LEF-1; E-CADHERIN; CYCLIN D1; EXPRESSION; ADHESION; MORPHOGENESIS; PATHWAY; TUMORS; TARGET; SKIN;
Keywords:
beta-catenin; a high temperature antigen unmasking technique; hair matrix cells; E-cadherin; terminal differentiation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Tsuji, H Asahikawa Med Coll, Dept Dermatol, 2-1-1-1 Midorigaoka Higashi, Asahikawa,Hokkaido 0788510, Japan Asahikawa Med Coll 2-1-1-1 Midorigaoka Higashi Asahikawa Hokkaido Japan 0788510
Citazione:
H. Tsuji et al., "Nuclear localization of beta-catenin in the hair matrix cells and differentiated keratinocytes", J DERMA SCI, 27(3), 2001, pp. 170-177

Abstract

beta -Catenin is a structural component of adherens junctions and also a downstream effector of Wnt signaling pathway. beta -Catenin has been detected in the adherens junctions in almost all normal tissues including the epidermis. Only in some malignant tumor cells was it found in the cytoplasm andnuclei. Recently pilomatricoma was found to be caused by mutations of amino-terminal segment of beta -catenin, normally involved in phosphorylation-dependent ubiquitin-mediated degradation of the protein. Since nuclear beta -catenin has not been detected in pilomatricoma or any other benign follicular tumors. we investigated localization of beta -catenin in the normal hair follicle, follicular tumor cells, normal and psoriatic epidermis by usingimmunohistochemical method with a high temperature antigen unmasking technique. The nuclear localization of beta -catenin was detected not only in the matrix cells of follicular tumors including pilomatricoma but also in thenormal hair matrix cells and the differentiated keratinocytes of the upperlayers of the epidermis. Cell membrane staining of beta -catenin and E-cadherin was decreased in these differentiated keratinocytes. This coincided with the emergence of nuclear beta -catenin. The present immunohistochemicalmethod has revealed hitherto unproven nuclear localization of beta -catenin in hair matrix cells. Our results also provided evidence suggesting that beta -catenin plays an important role in keratinocyte differentiation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:56:46