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Titolo:
Expression of AP-2 transcription factor and of its downstream target genesc-kit, E-cadherin and p21 in human cutaneous melanoma
Autore:
Baldi, A; Santini, D; Battista, T; Dragonetti, E; Ferranti, G; Petitti, T; Groeger, AM; Angelini, A; Rossiello, R; Baldi, F; Natali, PG; Paggi, MG;
Indirizzi:
Regina Elena Inst Canc Res, Ctr Expt Res, Lab Cell Metab & Pharmacokinet, I-00158 Rome, Italy Regina Elena Inst Canc Res Rome Italy I-00158 kinet, I-00158 Rome, Italy Campus Biomed Univ, Rome, Italy Campus Biomed Univ Rome ItalyCampus Biomed Univ, Rome, Italy Ctr Diagnost, Rome, Italy Ctr Diagnost Rome ItalyCtr Diagnost, Rome, Italy IDI, Serv Histopathol, Rome, Italy IDI Rome ItalyIDI, Serv Histopathol, Rome, Italy Univ Vienna, Dept Cardiothorac Surg, A-1010 Vienna, Austria Univ Vienna Vienna Austria A-1010 diothorac Surg, A-1010 Vienna, Austria Univ Naples 2, Dept Biochem & Biophys F Cedrangolo, Sect Pathol, Naples, Italy Univ Naples 2 Naples Italy hys F Cedrangolo, Sect Pathol, Naples, Italy Regina Elena Inst Canc Res, Ctr Expt Res, Immunol Lab, I-00161 Rome, ItalyRegina Elena Inst Canc Res Rome Italy I-00161 l Lab, I-00161 Rome, Italy
Titolo Testata:
JOURNAL OF CELLULAR BIOCHEMISTRY
fascicolo: 3, volume: 83, anno: 2001,
pagine: 364 - 372
SICI:
0730-2312(2001)83:3<364:EOATFA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALIGNANT-MELANOMA; DOWN-REGULATION; MOLECULAR MECHANISMS; TUMOR PROGRESSION; CELL-GROWTH; METASTASIS; CANCER; SUPPRESSION;
Keywords:
human skin melanoma; AP-2; p21; c-kit; E-cadherin; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Paggi, MG Regina Elena Inst Canc Res, Ctr Expt Res, Lab Cell Metab & Pharmacokinet, Via Messi dOro 156, I-00158 Rome, Italy Regina Elena Inst Canc Res Via Messi dOro 156 Rome Italy I-00158
Citazione:
A. Baldi et al., "Expression of AP-2 transcription factor and of its downstream target genesc-kit, E-cadherin and p21 in human cutaneous melanoma", J CELL BIOC, 83(3), 2001, pp. 364-372

Abstract

The AP-2 transcription factor plays a pivotal role in regulating the expression of several genes involved in tumor growth and progression of melanoma. We determined, by Western blot, variation in the level of expression of AP- and three of its downstream targets, c-kit, E-cadherin, and p21 in several human melanoma cell lines and, by immunohistochemistry, in a group of 99histological samples including benign and malignant melanocytic lesions. Asignificant negative correlation between AP-2 expression level and tumor thickness was found. Moreover, AP-2 expression was positively associated with E-cadherin and c-kit expression. In contrast, there was a significant negative association between AP-2 and p21 expression levels. These findings suggest that p21 is independent of AP-2 transactivator function during the latest phases of melanoma progression. Finally, AP-2, c-kit, E-cadherin, and p21 expression levels did not show to be able to distinguish between dysplastic nevi and nevi without dysplasia. We conclude that changes in the expression of these proteins are involved in the later phases of melanoma progression, and may be responsible for the transition from local invasive melanoma to metastasis. J. Cell. Biochem. 83: 364-372, 2001. (C) 2001 Wiley-Liss,Inc.

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Documento generato il 27/11/20 alle ore 06:47:45