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Titolo:
Patterns of adherence with antiretroviral medications: An examination of between-medication differences
Autore:
Wilson, IB; Tchetgen, E; Spiegelman, D;
Indirizzi:
New England Med Ctr 345, Div Clin Care Res, Boston, MA 02111 USA New England Med Ctr 345 Boston MA USA 02111 are Res, Boston, MA 02111 USA Tufts Univ New England Med Ctr, Dept Med, Boston, MA 02111 USA Tufts Univ New England Med Ctr Boston MA USA 02111 , Boston, MA 02111 USA Tufts Univ, Sch Med, Dept Family & Community Med, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 mily & Community Med, Boston, MA 02111 USA Harvard Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 pidemiol & Biostat, Boston, MA 02115 USA
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 3, volume: 28, anno: 2001,
pagine: 259 - 263
SICI:
1525-4135(20011101)28:3<259:POAWAM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
AIDS CLINICAL-TRIAL; HIV-INFECTION; THERAPY;
Keywords:
antiretroviral therapy; patient adherence; patient compliance; drug therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Wilson, IB New England Med Ctr 345, Div Clin Care Res, 750 Washington St, Boston, MA 02111 USA New England Med Ctr 345 750 Washington St Boston MA USA 02111 A
Citazione:
I.B. Wilson et al., "Patterns of adherence with antiretroviral medications: An examination of between-medication differences", J ACQ IMM D, 28(3), 2001, pp. 259-263

Abstract

Objective: To determine whether adherence with one antiretroviral medication reliably predicts adherence with other antiretroviral medications. Design: Cross-sectional repeated-measurement analysis. Setting: Cohort study enrolling patients from Massachusetts and Rhode Island. Patients: Total of 454 patients using antiretroviral medications for HIV infection. Methods: For each antiretroviral medication, we asked patients to report how many days in the last week they had 1) missed a dose of the medication and 2) been off schedule with a dose of the medication. The reliability coefficient was used to compare between-person variance in adherence rates withtotal variance, which is the sum of between-person and within-person variance. Results: The mean age of patients was 42 years; 28% were women and 37% were nonwhite. Sixty-six percent of patients were on three or more antiretroviral medications. Perfect adherence was reported by 42% of patients, and patients reported missing a dose on a mean of 1.5 days per week for each antiretroviral medication currently being taken. The reliability coefficient fordays in the last week that the medication was missed was 0.85 (95% confidence interval [Cl]: 0.83-0.87), and for days off-schedule in the last week, it was 0.88 (CI: 0.86-0.89). Conclusions: Most of the variability in antiretroviral adherence in this study was accounted for by between-patient differences in overall adherence rather than by within-patient differences in adherence patterns across medications. These data support the theory that when patients skip or are off schedule with doses, they skip or are off schedule with all the antiretroviral medications taken at that time. In the course of exploring patients' adherence issues, clinicians may rind it useful to inquire about problematic dosing times. Researchers assessing adherence may not need to separately monitor adherence with each antiretroviral medication in a regimen.

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Documento generato il 06/04/20 alle ore 00:00:31