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Titolo:
The dynamic of adherence to highly active antiretroviral therapy: Results from the French National APROCO cohort
Autore:
Carrieri, P; Cailleton, V; Le Moing, V; Spire, B; Dellamonica, P; Bouvet, E; Raffi, F; Journot, V; Moatti, JP;
Indirizzi:
INSERM, U379, F-13006 Marseille, France INSERM Marseille France F-13006INSERM, U379, F-13006 Marseille, France INSERM, U330, Bordeaux, France INSERM Bordeaux FranceINSERM, U330, Bordeaux, France Fac Xavier Bichat, Paris, France Fac Xavier Bichat Paris FranceFac Xavier Bichat, Paris, France LArchet Hosp, Nice, France LArchet Hosp Nice FranceLArchet Hosp, Nice, France Cochin Hosp, Paris, France Cochin Hosp Paris FranceCochin Hosp, Paris, France Hop Hotel Dieu, Nantes, France Hop Hotel Dieu Nantes FranceHop Hotel Dieu, Nantes, France
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 3, volume: 28, anno: 2001,
pagine: 232 - 239
SICI:
1525-4135(20011101)28:3<232:TDOATH>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIV-INFECTED PATIENTS; PROTEASE INHIBITOR THERAPY; SELF-REPORTED ADHERENCE; MEDICATION ADHERENCE; VIRAL LOAD; PREDICTORS; LAMIVUDINE; STAVUDINE; EFFICACY; COUNT;
Keywords:
HAART; adherence; HIV RNA; cohort study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Spire, B INSERM, U379, 23 Rue Stanislas Torrents, F-13006 Marseille, France INSERM 23 Rue Stanislas Torrents Marseille France F-13006 France
Citazione:
P. Carrieri et al., "The dynamic of adherence to highly active antiretroviral therapy: Results from the French National APROCO cohort", J ACQ IMM D, 28(3), 2001, pp. 232-239

Abstract

Objectives: Our objective was to describe the evolution of adherence to highly active antiretroviral therapy (HAART) over a 20-month period and its relationship with virologic success. Methods: Self-reported adherence, clinical, and virologic data Were collected 4 (M4), 12 (M12), and 20 (M20) months after initiation of a protease inhibitor-containing regimen in the French APROCO cohort. At each visit, patients were classified as nonadherent, moderately, or highly adherent, and HIV plasma RNA was determined. Results: Among the 762 patients who were regularly followed until M20, the436 patients who answered to all questionnaires, including adherence measurement, were selected for the analysis. The proportion of highly adherent patients was 55.7%, 62.2%, and 60.3% at M4, M12, and M20, respectively. A total of 137 patients (31.4%) was "always," 225 (51.6%) "sometimes," and 74 (17.0%) "never" "highly adherent" during follow-up. After multiple adjustment for known baseline predictors, virologic success after 20 months of HAARTwas more likely achieved in patients who were always (odds ratio [OR] 95% confidence interval [CI], 3.02 [1.64-5.58]) or sometimes (OR [95% Cl], 2.15[1.24-3.74]) "highly adherent. "Conclusion: Adherence behavior is a dynamic process. Continued adherence was associated with better response to therapy and should be encouraged to reduce the risk of virologic failure.

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Documento generato il 27/01/20 alle ore 02:10:37