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Titolo:
Treating systemic sclerosis in 2001
Autore:
Mouthon, L; Agard, C;
Indirizzi:
Univ Paris 13, Hop Avicenne, Dept Internal Med, F-93009 Bobigny, France Univ Paris 13 Bobigny France F-93009 ternal Med, F-93009 Bobigny, France Univ Paris 13, UPRES EA 2361, Bobigny, France Univ Paris 13 Bobigny France v Paris 13, UPRES EA 2361, Bobigny, France
Titolo Testata:
JOINT BONE SPINE
fascicolo: 5, volume: 68, anno: 2001,
pagine: 393 - 402
SICI:
1297-319X(200110)68:5<393:TSSI2>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLACEBO-CONTROLLED TRIAL; CRYPTOGENIC FIBROSING ALVEOLITIS; PRIMARY PULMONARY-HYPERTENSION; RECOMBINANT INTERFERON-GAMMA; TL-201 MYOCARDIAL PERFUSION; RANDOMIZED CONTROLLED TRIAL; CONNECTIVE-TISSUE DISEASE; INTERSTITIAL LUNG-DISEASE; CONTROLLED CLINICAL-TRIAL; SCLERODERMA RENAL CRISIS;
Keywords:
angiotensin-converting enzyme inhibitors cyclophosphamide; long-term treatment; peripheral stem cell transplant; scleroderma; symptomatic therapy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
99
Recensione:
Indirizzi per estratti:
Indirizzo: Mouthon, L Univ Paris 13, Hop Avicenne, Dept Internal Med, 125 Route Stalingrad, F-93009 Bobigny, France Univ Paris 13 125 Route Stalingrad Bobigny France F-93009 ance
Citazione:
L. Mouthon e C. Agard, "Treating systemic sclerosis in 2001", JOINT BONE, 68(5), 2001, pp. 393-402

Abstract

Systemic sclerosis (SS) is characterized by sclerosis of the dermis and internal organs and by vascular abnormalities. Although the pathophysiology of the disease has been partly elucidated, the efficacy of long-term treatments remains limited, with no significant increase in survival in prospective studies. Conventional drug treatments are disappointing in clinical practice, and in a recent prospective randomized study standard-dose D-penicillamine was not more effective than mini-dose D-penicillamine. New longterm treatments are emerging for diffuse SS, including cyclophosphamide for patients with progressive interstitial lung disease or stem cell transplantation for those with early organ involvement. The most effective treatments remain symptomatic, such as angiotensin-converting enzyme inhibitors for acute renal crisis, calcium channel antagonists for Raynaud's phenomenon, and proton pump inhibitors for the complications of gastroesophageal reflux. This review article focuses on long-term treatments that are most likely to be effective and suggests symptomatic treatment strategies tailored to specific organ involvements. Joint Bone Spine 2001; 68:393-402. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 23:14:14