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Titolo:
Comparative study of the leachability of di(2-ethylhexyl) phthalate and tri(2-ethylhexyl) trimellitate from haemodialysis tubing
Autore:
Kambia, K; Dine, T; Azar, R; Gressier, B; Luyckx, M; Brunet, C;
Indirizzi:
Fac Sci Pharmaceut & Biol, Lab Pharmacol Pharmacocinet & Pharm Clin, F-59006 Lille, France Fac Sci Pharmaceut & Biol Lille France F-59006 in, F-59006 Lille, France Ctr Hosp Gen Dunkerque, Dept Med Interne B, Serv Nephrol & Hemodialyse, F-59385 Dunkerque, France Ctr Hosp Gen Dunkerque Dunkerque France F-59385 -59385 Dunkerque, France
Titolo Testata:
INTERNATIONAL JOURNAL OF PHARMACEUTICS
fascicolo: 1-2, volume: 229, anno: 2001,
pagine: 139 - 146
SICI:
0378-5173(20011023)229:1-2<139:CSOTLO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
DI-2-ETHYLHEXYL PHTHALATE; PEROXISOME PROLIFERATORS; HEMODIALYSIS; EXPOSURE; RATS; CONTAINERS; DEHP; BAGS; ACID;
Keywords:
TOTM; DEHP; PVC; release; haemodialysis patients;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Dine, T Fac Sci Pharmaceut & Biol, Lab Pharmacol Pharmacocinet & Pharm Clin, 3 RueProfesseur Laguesse,BP 83, F-59006 Lille, France Fac Sci Pharmaceut& Biol 3 Rue Professeur Laguesse,BP 83 Lille France F-59006
Citazione:
K. Kambia et al., "Comparative study of the leachability of di(2-ethylhexyl) phthalate and tri(2-ethylhexyl) trimellitate from haemodialysis tubing", INT J PHARM, 229(1-2), 2001, pp. 139-146

Abstract

The leachability of both Di(2-ethylhexyl) phthalate (DEHP) and Tri(2-ethylhexyl) trimellitate (TEHTM) or Trioctyl trimellitate (TOTM) from haemodialysis tubing was investigated in 20 patients with chronic renal failure undergoing ga maintenance haemodialysis. The blood tubing made of common polyvinyl chloride (PVC) plasticized with DEHP (group I patients) were replaced with tubing plasticized with TOTM-DEHP (group 2 patients). The patient blood obtained from the inlet and the outlet of the dialyzer was analyzed during a 4 h-dialysis session. Thus, the circulating concentrations of both DEHP and TOTM resulting from the release from dialyzer tubes were estimated usingHigh-performance Liquid chromatograph (HPLC). With the common PVC-DEHP blood tubing, a DEHP quantity of 122.95 +/- 33.94 mg was extracted from tubingduring a single dialysis session (ranging from 55 to 166.21 mg). During the same period, the total amounts of DEHP retained by the patients were 27.30 +/- 9.22 mg (ranging from 12.50 to 42.72 mg). As for blood tubing plasticized with TOTM-DEHP, 41.80 +/- 4.47 mg of DEHP and 75.11 +/- 25.72 mg of TOTM were extracted. During the same period, the amounts of DEHP and TOTM retained by the patients were 3.42 +/- 1.37 mg and 4.87 +/- 2.60 mg, respectively. The extraction rate both plasticizers was correlated with serum lipid content (cholesterol + triglyceride) (r(2) = 0.75 for DEHP and r(2) = 0.64 for TOTM). In the present investigation, less TOTM and DEHP were apparentlyreleased from haemodialysis tubing plasticized with TOTM-DEHP than DEHP released from haemodialysis tubing plasticized with DEHP only. TOTM seems to be a Superior alternative to DEHP for use in medical devices because of itspotential lower leachability. To recommend it as an alternative plasticizer, its possible toxicity towards human body should be investigated before it can be used routinely. However, patients undergoing haemodialysis using tubing plasticized with DEHP only are regularly exposed to non negligible amounts of DEHP. In view of several biological effects previously reported, it is time to reconsider the use of DEHP only as a plasticizer. (C) 2001 Published by Elsevier Science BN.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 11:37:16