Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Erectile dysfunction occurs following substantia nigra lesions in the rat
Autore:
Zahran, AR; Simmerman, N; Carrier, S; Vachon, P;
Indirizzi:
MDS Pharma Serv, Dept Metab & Anim Pharmacokinet, Montreal, PQ H4R 2N6, Canada MDS Pharma Serv Montreal PQ Canada H4R 2N6 , Montreal, PQ H4R 2N6, Canada McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Dept Med, Montreal, PQ, Canada McGill Univ Montreal PQ Canada Gen Hosp, Dept Med, Montreal, PQ, Canada
Titolo Testata:
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
fascicolo: 5, volume: 13, anno: 2001,
pagine: 255 - 260
SICI:
0955-9930(200110)13:5<255:EDOFSN>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSONS-DISEASE; PENILE ERECTION; PARAVENTRICULAR NUCLEUS; APOMORPHINE; DOPAMINE; MODEL; 6-HYDROXYDOPAMINE; HYPOTHALAMUS; OXYTOCIN; INTACT;
Keywords:
rats; penile erection; apomorphine; intracavernous pressure; substantia nigra;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Vachon, P MDS Pharma Serv, Dept Metab & Anim Pharmacokinet, Ville St Laurent, Montreal, PQ H4R 2N6, Canada MDS Pharma Serv Ville St Laurent Montreal PQ Canada H4R 2N6 nada
Citazione:
A.R. Zahran et al., "Erectile dysfunction occurs following substantia nigra lesions in the rat", INT J IMPOT, 13(5), 2001, pp. 255-260

Abstract

Erectile function was assessed 6 weeks following uni- and bilateral injections of 6-hydroxydopamine in the substantia ni-ra nucleus of the brain. Behavioral apomorphine-induced penile erections were reduced (5/8) and increased (3/8) in uni- and bilateral lesioned animals. Intracavernous pressures, following electrical stimulation of the cavernous nerve, decreased in lesioned animals. Lesions of the substantia nigra were confirmed by histology. Concentration of dopamine and its metabolites were decreased in the striatumof substantia nigra lesioned rats. Lesions of the substantia nigra are therefore associated with erectile dysfunction in rats and may serve as a model to study erectile dysfunction in Parkinson's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:31:03