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Titolo:
Influence of diminished susceptibility of Streptococcus pneumoniae to ciprofloxacin on the serum bactericidal activity of gemifloxacin and trovafloxacin after a single dose in healthy volunteers
Autore:
Prieto, J; Aguilar, L; Fuentes, F; Gimenez, MJ; Alou, L; Dal-Re, R; Sorgel, F; Frias, J;
Indirizzi:
Univ Complutense Madrid, Sch Med, Dept Microbiol, E-28040 Madrid, Spain Univ Complutense Madrid Madrid Spain E-28040 biol, E-28040 Madrid, Spain GlaxoSmithKline, Dept Med, Madrid 28760, Spain GlaxoSmithKline Madrid Spain 28760 hKline, Dept Med, Madrid 28760, Spain Pharmaceut Res Inst, IBMP, D-90562 Nurnberg, Germany Pharmaceut Res Inst Nurnberg Germany D-90562 , D-90562 Nurnberg, Germany Univ Autonoma Madrid, Sch Med, Clin Pharmacol Unit, Madrid 28029, Spain Univ Autonoma Madrid Madrid Spain 28029 rmacol Unit, Madrid 28029, Spain
Titolo Testata:
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
fascicolo: 3, volume: 18, anno: 2001,
pagine: 231 - 238
SICI:
0924-8579(2001)18:3<231:IODSOS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMMUNITY-ACQUIRED PNEUMONIA; IN-VITRO SUSCEPTIBILITY; ANTIMICROBIAL RESISTANCE; PHARMACOKINETICS; INFECTIONS; SPAIN; CEFTIZOXIME; CEFOTAXIME; STRAINS; THERAPY;
Keywords:
Streptococcus pneumoniae; serum bactericidal activity; gemifloxacin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Prieto, J Univ Complutense Madrid, Sch Med, Dept Microbiol, Avda Complutense S-N, E-28040 Madrid, Spain Univ Complutense Madrid Avda Complutense S-N Madrid Spain E-28040
Citazione:
J. Prieto et al., "Influence of diminished susceptibility of Streptococcus pneumoniae to ciprofloxacin on the serum bactericidal activity of gemifloxacin and trovafloxacin after a single dose in healthy volunteers", INT J ANT A, 18(3), 2001, pp. 231-238

Abstract

The serum bactericidal activity against 2 Streptococcus pneumoniae strains(ciprofloxacin MIC 1 and 4 mg/l) was measured in 12 volunteers who received oral single doses of gemifloxacin 320 mg and trovafloxacin 200 mg in a crossover fashion. The 4-fold increase in ciprofloxacin MIC from the susceptible to the resistant strain resulted in a 2-fold increase in MIC (from 0.015 to 0.03 mg/l), a 2-fold decrease in C-max/MIC (104 vs 52) and in AUC(0-24h)/MIC (532 vs 266), but a 5.6-fold decrease in area under the bactericidal curve (AUBC: 168 vs 30) for gemifloxacin. Trovafloxacin showed a 4-fold higher MIC (0.25 vs 0.06 mg.l), a 4-fold lower C-max/MIC (8.6 vs 36), a 4-fold lower AUC(0-24) (h)/MIC (85 vs 356) and a 11-fold lower AUBCs (2 vs 22) against the resistant isolate compared with the susceptible one. Trovafloxacin serum bactericidal titres against the ciprofloxacin-resistant strain were measurable generally only at 1 h after dosing (median titre = 2). Gemifloxacin showed similar ex vivo bactericidal activity against the ciprofloxacin-resist ant strain to that of trovafloxacin against the ciprofloxacin-susceptible strain. (C) 2001 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.

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Documento generato il 05/12/20 alle ore 06:56:25