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Titolo:
Effects of azoles on human acute myelogenous leukemia blasts and T lymphocytes derived from acute leukemia patients with chemotherapy-induced cytopenia
Autore:
Bruserud, O;
Indirizzi:
Haukeland Univ Hosp, Dept Med, Div Hematol, N-5021 Bergen, Norway Haukeland Univ Hosp Bergen Norway N-5021 Hematol, N-5021 Bergen, Norway Univ Bergen, N-5021 Bergen, Norway Univ Bergen Bergen Norway N-5021Univ Bergen, N-5021 Bergen, Norway
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 12, volume: 1, anno: 2001,
pagine: 2183 - 2195
SICI:
1567-5769(200111)1:12<2183:EOAOHA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYELOID-LEUKEMIA; BONE-MARROW TRANSPLANTATION; NEUTROPENIC CANCER-PATIENTS; PLACEBO-CONTROLLED TRIAL; INDUCED LEUKOPENIA; AMPHOTERICIN-B; POSTREMISSION CHEMOTHERAPY; ANTIFUNGAL THERAPY; FUNGAL-INFECTIONS; ACCESSORY CELLS;
Keywords:
fluconazole; itraconazole; ketoconazole; miconazole; T lymphocytes; acute myelogenous leukemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Bruserud, O Haukeland Univ Hosp, Dept Med, Div Hematol, N-5021 Bergen, Norway Haukeland Univ Hosp Bergen Norway N-5021 5021 Bergen, Norway
Citazione:
O. Bruserud, "Effects of azoles on human acute myelogenous leukemia blasts and T lymphocytes derived from acute leukemia patients with chemotherapy-induced cytopenia", INT IMMUNO, 1(12), 2001, pp. 2183-2195

Abstract

The effects of azoles (fluconazole, ketoconazole, miconazole, itraconazole) on human acute myelogenous leukemia (AML) blasts and T lymphocytes were studied in vitro. All the azoles altered spontaneous proliferation, cytokine-dependent proliferation and constitutive cytokine secretion by native AML blasts for a subset of patients, and all the drugs then had divergent effects. All four drugs also affected the responsiveness (cytokine-dependent andmitogen-stimulated proliferation, cytokine release) of clonogenic CD4(+) and CD8(+) T cells derived from acute leukemia patients with chemotherapy-induced cytopenia. However, the T cell effects were also divergent and dependent on differences between various azoles, AML accessory cells and mitogenic activation signals. These drug effects may have a clinical relevance in acute leukemia patients receiving intensive chemotherapy together with azoles as prophylaxis or treatment for fungal infections: (i) effects on AML blasts may influence their susceptibility to drug-induced apoptosis; and (ii) effects on T cells may alter effector functions that mediate additional antileukemic effects in patients receiving intensive chemotherapy. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 14:33:01