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Titolo:
Protection of T cells from radiation-induced apoptosis by Cepharanthin (R)
Autore:
Oyaizu, H; Adachi, Y; Yasumizu, R; Ono, M; Ikebukuro, K; Fukuhara, S; Ikehara, S;
Indirizzi:
Kansai Med Univ, Dept Pathol 1, Moriguchi, Osaka 570, Japan Kansai Med Univ Moriguchi Osaka Japan 570 1, Moriguchi, Osaka 570, Japan Kansai Med Univ, Dept Internal Med 1, Osaka, Japan Kansai Med Univ OsakaJapan Med Univ, Dept Internal Med 1, Osaka, Japan Kaken Shoyaku Co Ltd, Tokyo, Japan Kaken Shoyaku Co Ltd Tokyo JapanKaken Shoyaku Co Ltd, Tokyo, Japan Kansai Med Univ, Dept Surg 2, Osaka, Japan Kansai Med Univ Osaka JapanKansai Med Univ, Dept Surg 2, Osaka, Japan
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 12, volume: 1, anno: 2001,
pagine: 2091 - 2099
SICI:
1567-5769(200111)1:12<2091:POTCFR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MITOCHONDRIAL-MEMBRANE PROTEIN; IN-VIVO; LYMPHOCYTE APOPTOSIS; GAMMA-IRRADIATION; DOWN-MODULATION; DNA-DAMAGE; BCL-2; BAX; EXPRESSION; DEATH;
Keywords:
Cepharanthin; mitochondrial transmembrane potential (Delta psi(m)); radiation; apoptosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Ikehara, S Kansai Med Univ, Dept Pathol 1, 10-15 Fumizonocho, Moriguchi, Osaka 570, Japan Kansai Med Univ 10-15 Fumizonocho Moriguchi Osaka Japan 570pan
Citazione:
H. Oyaizu et al., "Protection of T cells from radiation-induced apoptosis by Cepharanthin (R)", INT IMMUNO, 1(12), 2001, pp. 2091-2099

Abstract

Cepharanthin((R)) (CE) is a medicine that contains several biscoclaurine alkaloids. We examined the effects of CE on radiation-induced T cell apoptosis. Radiation induced apoptosis on T cells in a dose-dependent manner, while CE inhibited radiation-induced apoptosis. CE also attenuated the cytotoxic effects of radiation on the proliferative response of T cells. CE inhibited not only the loss of mitochondrial transmembrane potential but also the activation of caspase 3 in irradiated T cells. Radiation plus CE induced the up-regulation of Bax and the down-regulation of Bcl-2 in T cells in comparison with radiation alone. These results suggest that CE inhibits the signal transduction pathway of apoptosis induced by radiation, regardless of the expression of Bcl-2 or Bax. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 10:42:18