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Titolo:
Flt3 ligand: a novel cytokine prevents allergic asthma in a mouse model
Autore:
Agrawal, DK; Hopfenspirger, MT; Chavez, J; Talmadge, JE;
Indirizzi:
Creighton Univ, Sch Med, Dept Med, Ctr Allergy Asthma & Immunol, Omaha, NE68178 USA Creighton Univ Omaha NE USA 68178 gy Asthma & Immunol, Omaha, NE68178 USA Univ Nebraska, Med Ctr, Dept Pathol & Microbiol, Omaha, NE 68198 USA Univ Nebraska Omaha NE USA 68198 Pathol & Microbiol, Omaha, NE 68198 USA
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 12, volume: 1, anno: 2001,
pagine: 2081 - 2089
SICI:
1567-5769(200111)1:12<2081:FLANCP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; HEMATOPOIETIC PROGENITOR CELLS; EARLY BCG VACCINATION; IN-VIVO; DENDRITIC CELLS; NATURAL-KILLER; MURINE MODEL; HUMAN HOMOLOG; T-LYMPHOCYTE; STEM-CELLS;
Keywords:
airway hyperresponsiveness; asthma; eosinophilia; Flt-3 ligand; late allergic response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Agrawal, DK Creighton Univ, Sch Med, Dept Med, Ctr Allergy Asthma & Immunol, CRISS 1 Room 131,2500 Calif Plaza, Omaha, NE 68178 USA Creighton Univ CRISS 1 Room 131,2500 Calif Plaza Omaha NE USA 68178
Citazione:
D.K. Agrawal et al., "Flt3 ligand: a novel cytokine prevents allergic asthma in a mouse model", INT IMMUNO, 1(12), 2001, pp. 2081-2089

Abstract

Flt-3 ligand (FL), a recently described growth factor affecting early hematopoietic progenitor cells, can also support the expansion of dendritic cells secreting IL-12. Since type 2 T cells predominate in asthma and IL-12 prevents the differentiation of naive T lymphocytes to a type 2 phenotype, wehypothesized that FL could prevent the development of asthma-like conditions in the ovalbumin mouse model. We found that co-administration of FL during ovalbumin sensitization abrogated late allergic responses, but had no effect on early allergic responses. Airway hyperresponsiveness to methacholine was also blocked by FL treatment. Analysis of bronchoalveolar lavage (BAL) fluid demonstrated a significant reduction in eosinophils, with concomitant decreases in IL-5 and increases in IFN-gamma levels. However, there was no change in BAL fluid IL-4 and serum IgE levels. These data suggest that FL treatment prevents ovalbumin-induced asthma in the mouse and may provide a useful adjuvant in the treatment of human asthma. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 18/01/20 alle ore 02:42:42