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Titolo:
Comparison of tissue kallikrein and kinin receptor expression in gastric ulcers and neoplasms
Autore:
Sawant, S; Snyman, C; Bhoola, K;
Indirizzi:
Technikon Natal, Ctr Res Dev, Fac Hlth, ZA-4000 Durban, South Africa Technikon Natal Durban South Africa ZA-4000 ZA-4000 Durban, South Africa Tata Mem Hosp, Inst Canc Res, Bombay 400012, Maharashtra, India Tata Mem Hosp Bombay Maharashtra India 400012 400012, Maharashtra, India
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 12, volume: 1, anno: 2001,
pagine: 2063 - 2080
SICI:
1567-5769(200111)1:12<2063:COTKAK>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRADYKININ; DES-ARG9-BRADYKININ; VISUALIZATION; NEUTROPHILS; FIBROBLASTS; SECRETION; PROTEIN; RAT;
Keywords:
peptic ulcers; gastric tumours; confocal and electron microscopy; image analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Bhoola, K Technikon Natal, Ctr Res Dev, Fac Hlth, POB 953, ZA-4000 Durban,South Africa Technikon Natal POB 953 Durban South Africa ZA-4000 outh Africa
Citazione:
S. Sawant et al., "Comparison of tissue kallikrein and kinin receptor expression in gastric ulcers and neoplasms", INT IMMUNO, 1(12), 2001, pp. 2063-2080

Abstract

Recent studies have suggested the possible involvement of the kallikrein-kinin cascade in gastric inflammatory diseases and malignant transformation in peptic ulcers. Germ-line mutations of genes responsible for repairing DNA mismatch may cause the transformation of chronic peptic ulceration to malignancy. The aim of the study was to compare the expression of the serine protease, tissue kallikrein (TK) and kinin peptide receptors, B1 and B2, in human gastric carcinoma and ulcers. Furthermore, experiments were designed to ask the question whether holistic changes known to occur in carcinoma would be reflected in the expression of the neutrophil kallikrein-kinin cascade. Expression of tissue kallikrein and kinin receptors in both tumour and ulcer tissue and circulating neutrophils of cancer and ulcer patients was determined by immunolabelling techniques, using specific antibodies. The immunolabelled images were visualised by light, confocal and electron microscopy. This is a first study that provides strong evidence for enhanced expression of TK in peptic ulceration and gastric malignancy, suggestive of a crucial role for serine proteases in cancer. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 11:02:04