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Titolo:
Factors modifying the migration of lymphocytes across the blood-brain barrier
Autore:
Brown, KA;
Indirizzi:
Guys Hosp, Dept Immunobiol, London SE1 9RT, England Guys Hosp London England SE1 9RT ept Immunobiol, London SE1 9RT, England
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 12, volume: 1, anno: 2001,
pagine: 2043 - 2062
SICI:
1567-5769(200111)1:12<2043:FMTMOL>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; TUMOR-NECROSIS-FACTOR; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; MULTIPLE-SCLEROSIS PATIENTS; SOLUBLE ADHESION MOLECULES; MYELIN BASIC-PROTEIN; IN-SITU HYBRIDIZATION; T-CELL RECEPTOR; MATRIX-METALLOPROTEINASE EXPRESSION;
Keywords:
lymphocyte; blood; brain;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
174
Recensione:
Indirizzi per estratti:
Indirizzo: Brown, KA Guys Hosp, Dept Immunobiol, 3rd Floor New Guys House, London SE19RT, England Guys Hosp 3rd Floor New Guys House London England SE1 9RT gland
Citazione:
K.A. Brown, "Factors modifying the migration of lymphocytes across the blood-brain barrier", INT IMMUNO, 1(12), 2001, pp. 2043-2062

Abstract

Characterising the factors that control the entry of leucocytes into tissue in response to inflammatory or microbial insult continues to generate considerable interest. Of all the tissues studied it is probably that of the CNS which is the most fascinating because of the specialised properties of its blood vessel walls, which constitute the blood-brain barrier (BBB). In health, very few leucocytes penetrate the BBB but in disorders such as MS the barrier becomes compromised with the result that there is an intense infiltration of the CNS by T lymphocytes whose subsequent activity appears to underlie the onset and progression of disease. The purpose of this article is to summarise and assess recent literature pertaining to how lymphocytes bind to cerebral endothelial cells, migrate across the blood vessel walls and enter the CNS parenchyma. Particular emphasis is devoted to the cellular and molecular aspects of these events and addressing the questions of whether certain subsets of circulating T lymphocytes are more favourably disposed than others to CNS infiltration and whether entry is dependent upon the initial expression of distinct groups of adhesion molecules and upon the generation of chemotactic factors. This article also focuses upon identifying the key stages of lymphocyte migration across the BBB and their susceptibility to antagonism by therapeutic agents. It is intended that the review will provide a useful source of information and offer additional insights intothe mechanisms controlling lymphocyte passage across the BBB during pathological disturbance. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:24:42