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Titolo:
Predictors of response to pharmacotherapy with citalopram in obsessive-compulsive disorder
Autore:
Stein, DJ; Montgomery, SA; Kasper, S; Tanghoj, P;
Indirizzi:
Univ Stellenbosch, Dept Psychiat, MRC, Res Unit Anxiety Disorders, ZA-7505Cape Town, South Africa Univ Stellenbosch Cape Town South Africa ZA-7505 Cape Town, South Africa Univ Florida, Gainesville, FL USA Univ Florida Gainesville FL USAUniv Florida, Gainesville, FL USA Univ London Imperial Coll Sci Technol & Med, Dept Pharmacol, London, England Univ London Imperial Coll Sci Technol & Med London England don, England Univ Vienna, Dept Gen Psychiat, Vienna, Austria Univ Vienna Vienna Austria v Vienna, Dept Gen Psychiat, Vienna, Austria H Lundbeck & Co AS, Copenhagen, Denmark H Lundbeck & Co AS Copenhagen Denmark beck & Co AS, Copenhagen, Denmark
Titolo Testata:
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
fascicolo: 6, volume: 16, anno: 2001,
pagine: 357 - 361
SICI:
0268-1315(200111)16:6<357:PORTPW>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN HYPOTHESIS; CLOMIPRAMINE; METAANALYSIS; ADOLESCENTS; FLUVOXAMINE; EFFICACY; CHILDREN;
Keywords:
obsessive-compulsive disorder; serotonin reuptake inhibitors; citalopram; predictors of response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Stein, DJ Univ Stellenbosch, Dept Psychiat, MRC, Res Unit Anxiety Disorders, POB 19063, ZA-7505 Cape Town, South Africa Univ Stellenbosch POB 19063 Cape Town South Africa ZA-7505 rica
Citazione:
D.J. Stein et al., "Predictors of response to pharmacotherapy with citalopram in obsessive-compulsive disorder", INT CLIN PS, 16(6), 2001, pp. 357-361

Abstract

Although serotonin reuptake inhibitors (SRIs) are the medications of choice in the treatment of obsessive-compulsive disorder (OCD), only 50-60% of patients respond to a single trial of any of these agents. Improved knowledge of the predictors of response to treatment may have important clinical implications. Data from a large randomized placebo-controlled trial of citalopram in OCD was analysed using logistic regression to determine predictors of response. Demographic (age, sex), clinical (OCD severity and duration, depression severity, prior treatment) and trial variables (citalopram dose, treatment duration) were included. Subjects with longer duration of OCD, more severe OCD symptoms or previous selective SRI use were less likely to beresponders in the citalopram trial. In contrast, subjects who received adequate medication doses for sufficient periods of time in the citalopram trial were more likely to be responders. Despite greater awareness of OCD in recent years, there is evidence that the disorder continues to be underdiagnosed and undertreated. The data here emphasize the crucial importance of early diagnosis and treatment of OCD, and of pharmacotherapy with appropriatedose and duration.(C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:14:22