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Titolo:
Hippocampal dysfunction in schizophrenia
Autore:
Schmajuk, NA;
Indirizzi:
Duke Univ, Dept Psychol, Durham, NC 27706 USA Duke Univ Durham NC USA 27706 ke Univ, Dept Psychol, Durham, NC 27706 USA
Titolo Testata:
HIPPOCAMPUS
fascicolo: 5, volume: 11, anno: 2001,
pagine: 599 - 613
SICI:
1050-9631(2001)11:5<599:HDIS>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURAL-NETWORK APPROACH; LATENT INHIBITION; NUCLEUS-ACCUMBENS; BASAL GANGLIA; PREFRONTAL CORTEX; STIMULUS CONFIGURATION; PARAHIPPOCAMPAL GYRUS; UNRESTRAINED RATS; MONOZYGOTIC TWINS; PYRAMIDAL CELL;
Keywords:
schizophrenia; latent inhibition; neural network; dopamine; haloperidol; nucleus accumbens; hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
84
Recensione:
Indirizzi per estratti:
Indirizzo: Schmajuk, NA Duke Univ, Dept Expt Psychol, Durham, NC 27706 USA Duke UnivDurham NC USA 27706 Psychol, Durham, NC 27706 USA
Citazione:
N.A. Schmajuk, "Hippocampal dysfunction in schizophrenia", HIPPOCAMPUS, 11(5), 2001, pp. 599-613

Abstract

Although not necessarily primary to the disease, hippocampal dysfunction in schizophrenia is suggested by morphological changes in the hippocampal formation reported in schizophrenic patients. This notion receives additionalsupport from studies showing that 1) similar behavioral deficits are exhibited by both schizophrenics and animals with hippocampal lesions, and 2) some of these behavioral deficits are reversed by neuroleptics in both schizophrenics and lesioned animals. A brain-mapped neural network model is used to explain how some impairments in attention can be caused by hippocampal dysfunction and ameliorated by dopaminergic blockers. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:23:06