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Titolo:
GluR(5,6,7) subunit immunoreactivity on apical pyramidal cell dendrites inhippocampus of schizophrenics and manic depressives
Autore:
Benes, FM; Todtenkopf, MS; Kostoulakos, P;
Indirizzi:
McLean Hosp, Struct Neurosci Lab, Belmont, MA 02178 USA McLean Hosp Belmont MA USA 02178 ruct Neurosci Lab, Belmont, MA 02178 USA Harvard Univ, Sch Med, Program Neurosci, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 , Program Neurosci, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Med, Dept Psychiat, Boston, MA 02115 USA
Titolo Testata:
HIPPOCAMPUS
fascicolo: 5, volume: 11, anno: 2001,
pagine: 482 - 491
SICI:
1050-9631(2001)11:5<482:GSIOAP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMATE-RECEPTOR SUBUNIT; KAINATE RECEPTORS; GLUR6-DEFICIENT MICE; PREFRONTAL CORTEX; MONKEY NEOCORTEX; BINDING; NEURONS; BRAIN; RAT; CA3;
Keywords:
GlurR(5,6,7); subunits; hippocampus; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Benes, FM McLean Hosp, Struct Neurosci Lab, 115 Mill St, Belmont, MA 02178USA McLean Hosp 115 Mill St Belmont MA USA 02178 lmont, MA 02178 USA
Citazione:
F.M. Benes et al., "GluR(5,6,7) subunit immunoreactivity on apical pyramidal cell dendrites inhippocampus of schizophrenics and manic depressives", HIPPOCAMPUS, 11(5), 2001, pp. 482-491

Abstract

Recent postmortem studies have suggested that changes in the regulation ofkainate-sensitive glutamate receptors (kainate receptors) in the hippocampus may play a role in schizophrenia. To explore this possibility further, the distribution of immunoreactivity (IR) for the GluR(5,6,7) Subunits of the KR was assessed in a cohort consisting of 15 normal controls, 15 schizophrenics, and 9 manic depressives matched for age and postmortem interval (PMI). Cross sections of hippocampus showed abundant GluR(5,6,7)-IR on apical dendrites of pyramidal neurons in the stratum radiatum and stratum moleculare. in normal controls, both the numerical and length density of IR dendrites were much higher in sector CA2 than in sectors CA3 or CAI. When data forthe individual groups were separately examined, the schizophrenics showed a 30-35% reduction in the density of GluR(5,6,7)-IR dendrites found in bothstratum radiatum and stratum molecular of sectors CA3 and CA2, as well as proximal and middle portions of CAI. In CA2, the magnitude of this decreasein schizophrenia was 2.5 times larger than that seen in any of the other sectors. For the manic depressive group, no significant differences were observed in any sectors or laminae examined. The potential confounding effectsof either age, PMI, or neuroleptic exposure do not explain the reduced density of IR dendrites detected in the schizophrenic group. Taken together, the preferential reduction of GluR(5,6,7)-IR observed, on apical dendrites of pyramidal neurons is consistent with a functional downregulation of the kainate receptor in the hippocampus of schizophrenic brain. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 04/06/20 alle ore 01:49:30