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Titolo:
Cytokine profile of serum and bronchoalveolar lavage fluids following thoracic esophageal cancer surgery
Autore:
Sato, N; Koeda, K; Kimura, Y; Ikeda, K; Ogawa, M; Saito, K; Endo, S;
Indirizzi:
Iwate Med Univ, Sch Med, Dept Surg 1, Morioka, Iwate 0208505, Japan Iwate Med Univ Morioka Iwate Japan 0208505 Morioka, Iwate 0208505, Japan Iwate Med Univ, Sch Med, Dept Crit Care & Emergency Med, Morioka, Iwate 0208505, Japan Iwate Med Univ Morioka Iwate Japan 0208505 Morioka, Iwate 0208505, Japan
Titolo Testata:
EUROPEAN SURGICAL RESEARCH
fascicolo: 4, volume: 33, anno: 2001,
pagine: 279 - 284
SICI:
0014-312X(200107/08)33:4<279:CPOSAB>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-6; BLOOD;
Keywords:
IL-8; IL-10; IL-1ra; soluble tumor necrosis factor receptor I; systemic inflammatory response syndrome; compensatory anti-inflammatory response syndrome; bronchoalveolar lavage fluid; surgical stress; esophageal cancer; cytokine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Sato, N Iwate Med Univ, Sch Med, Dept Surg 1, 19-1 Uchimaru, Morioka, Iwate 0208505, Japan Iwate Med Univ 19-1 Uchimaru Morioka Iwate Japan 0208505 05, Japan
Citazione:
N. Sato et al., "Cytokine profile of serum and bronchoalveolar lavage fluids following thoracic esophageal cancer surgery", EUR SURG RE, 33(4), 2001, pp. 279-284

Abstract

Objectives: The body's response to stress is comprised of two opposing reactions, namely inflammation and immunosuppression. The balance between these two reactions not only changes over time, but also varies among differentcells or organs. Limited information is available regarding the cytokine balance of circulating blood and inflammatory sites after thoracic surgical stress. Design:The subjects of the present study were 10 patients undergoing esophageal cancer surgery which requires thoracolaparotomic manipulation. The postoperative levels of interleukin (IL)-8, IL-10, IL-1 receptor antagonist (IL-1ra) and soluble tumor necrosis factor receptor I (sTNF-RI) in bronchoalveolar lavage fluids (BALFs) and peripheral blood were measured by enzyme-linked immunosorbent assay. The absolute concentration of cytokines in lower respiratory tract ([cytokine](LRT)) was estimated by using the ratio of urea concentration in BALF and serum. Results: The levels of these cytokines in peripheral blood peaked within 24 h of start of the surgery (IL-885.6 +/- 29.8 pg/ml; IL-10 65.1 +/- 10.6 pg/ml; IL-1ra 2,807.8 +/- 652.8 pg/ml, and sTNF-RI 3,996.3 +/- 380.1 pg/ml). The level of [IL-8](LRT) immediately after surgery was approximately 20 times higher than that in peripheral blood, and the level of [IL-1ra](LRT) was approximately 4 times higher. In contrast, the level of [IL-10](LRT) immediately after surgery was comparable to that in peripheral blood, but the level of [sTNF RI](LRT) immediately after surgery was approximately one fifth of that in peripheral blood. Conclusions: The balance between pro- and anti-inflammatory reactions variesfrom one part of the body to the next, and changes over time after surgery. The profile of stress-induced pro-inflammatory cytokines and anti-inflammatory cytokines should be analyzed further to establish appropriate and effective cytokine modulatory therapeutic approaches. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 10:44:34