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Titolo:
Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats
Autore:
Gittos, MW; Papp, M;
Indirizzi:
Polish Acad Sci, Inst Pharmacol, PL-31343 Krakow, Poland Polish Acad Sci Krakow Poland PL-31343 harmacol, PL-31343 Krakow, Poland Anda Biol, F-67000 Strasbourg, France Anda Biol Strasbourg France F-67000 nda Biol, F-67000 Strasbourg, France
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 5, volume: 11, anno: 2001,
pagine: 351 - 357
SICI:
0924-977X(200110)11:5<351:AAOA2A>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
FORCED SWIMMING TEST; INDUCED ANHEDONIA; NUCLEUS-ACCUMBENS; RECEPTOR-BINDING; CHANNEL; FLUOXETINE; MECHANISM; DRUGS; BRAIN; IMIPRAMINE;
Keywords:
AGN 2979; imipramine; tryptophan hydroxylase inhibition; chronic stress; depression; antidepressant action; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Papp, M Polish Acad Sci, Inst Pharmacol, 12 Smetna St, PL-31343 Krakow, Poland Polish Acad Sci 12 Smetna St Krakow Poland PL-31343 rakow, Poland
Citazione:
M.W. Gittos e M. Papp, "Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats", EUR NEUROPS, 11(5), 2001, pp. 351-357

Abstract

Chronic mild stress (CMS) procedure was used to study an anti depressant-like activity of AGN 2979, a selective inhibitor of tryptophan hydroxylase (TH) activation. At the dose of 4 mg/kg, AGN 2979 fully reversed the CMS-induced reduction in the consumption of 1% sucrose solution. This effect was maintained for at least I week after cessation of treatment and no signs of withdrawal were observed in either stressed or control animals receiving AGN 2979. The lower (1 mg/kg) and higher (16 mg/kg) doses were ineffective. The magnitude of action of AGN 2979 in the CMS model was comparable to that of imipramine ( 10 mg/kg) but its onset of action appears to be faster since the inhibition of sucrose intake in stressed animals was already reversedafter the 1st week of AGN 2979 administration while imipramine required 3 weeks of treatment to cause similar effect. These results provide support for the hypothesis that inhibition of TH activation may result in a potent antidepressant activity. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:23:19