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Titolo:
Prevention of the stress-induced increase in frontal cortical dopamine efflux of freely moving rats by long-term treatment with antidepressant drugs
Autore:
Dazzi, L; Serra, M; Spiga, F; Pisu, MG; Jentsch, JD; Biggio, G;
Indirizzi:
Univ Cagliari, Dept Expt Biol B Loddo, I-09123 Cagliari, Italy Univ Cagliari Cagliari Italy I-09123 ol B Loddo, I-09123 Cagliari, Italy Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 , Dept Psychiat, New Haven, CT 06520 USA
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 5, volume: 11, anno: 2001,
pagine: 343 - 349
SICI:
0924-977X(200110)11:5<343:POTSII>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; MAJOR DEPRESSION; PREFRONTAL CORTEX; NEUROACTIVE STEROIDS; RELEASE; BRAIN; MIRTAZAPINE; RECEPTOR; NEURONS; ABUSE;
Keywords:
antidepressant drugs; stress; dopamine release; microdialysis; neuroactive steroids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Dazzi, L Univ Cagliari, Dept Expt Biol B Loddo, I-09123 Cagliari, Italy Univ Cagliari Cagliari Italy I-09123 o, I-09123 Cagliari, Italy
Citazione:
L. Dazzi et al., "Prevention of the stress-induced increase in frontal cortical dopamine efflux of freely moving rats by long-term treatment with antidepressant drugs", EUR NEUROPS, 11(5), 2001, pp. 343-349

Abstract

Use of antidepressant drugs in the treatment of anxiety disorders has recently increased due to the anxiolytic effect of some of these agents. Because dopaminergic transmission in the prefrontal cortex is sensitive to anxiogenic or stressful stimuli, the effects of two antidepressant drugs with different mechanisms of action, imipramine and mirtazapine, on the response ofrat cortical dopaminergic neurons to stress were investigated. A 2-week (but not single dose) administration of imipramine (10 mg/kg, i.p., twice daily) or mirtazapine (10 mg/kg, i.p., once daily) reduced and completely antagonized, respectively, the increase in dopamine release in the prefrontal cortex elicited by footshock stress, Long-term administration of imipramine or mirtazapine had no marked effect on the stress-induced increases in the brain or plasma concentrations of neuroactive steroids or corticosterone. An attenuation of the response of mesocortical dopaminergic neurons to stress induced by long-term treatment with antidepressants might contribute to the anxiolytic effects of such drugs. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:44:55